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吡咯烷二硫代氨基甲酸盐和二乙基二硫代氨基甲酸盐对生长状态和非生长状态的结核分枝杆菌持留菌均有活性。

Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis.

作者信息

Byrne Sean T, Gu Peihua, Zhou Jiangbing, Denkin Steven M, Chong Curtis, Sullivan David, Liu Jun O, Zhang Ying

机构信息

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.

出版信息

Antimicrob Agents Chemother. 2007 Dec;51(12):4495-7. doi: 10.1128/AAC.00753-07. Epub 2007 Sep 17.

DOI:10.1128/AAC.00753-07
PMID:17876006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2168016/
Abstract

Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 microg/ml and 0.13 microg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.

摘要

二乙氨基二硫代甲酸盐（DETC）和吡咯烷二硫代甲酸盐（PDTC）对结核杆菌具有高活性，其最低抑菌浓度（MIC）分别为8微克/毫升和0.13微克/毫升。DETC和PDTC对陈旧培养物有活性，增强了吡嗪酰胺或吡嗪酰胺/利福平的活性，并且在口服给予100毫克/千克的小鼠中，血清抑制效价分别为1:2和1:4。

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Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target.将1型肌苷单磷酸脱氢酶鉴定为抗血管生成药物靶点。
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