Sankar D, Rao M Ramakrishna, Sambandam G, Pugalendi K V
Department of Biotechnology, Aarupadai Veedu Institute of Technology, Vinayaka Mission's Research Foundation University, Paiyanoor-603104, Chennai, Tamilnadu, India.
Yale J Biol Med. 2006 Mar;79(1):19-26.
The study was undertaken to investigate the effect of sesame oil in hypertensive patients who were on antihypertensive therapy either with diuretics (hydrochlorothiazide) or Beta-blockers (atenolol). Thirty-two male and 18 female patients aged 35 to 60 years old were supplied sesame oil (Idhayam gingelly oil) and instructed to use it as the only edible oil for 45 days. Blood pressure, anthropometry, lipid profile, lipid peroxidation, and enzymic and non-enzymic antioxidants were measured at baseline and after 45 days of sesame oil substitution. Substitution of sesame oil brought down systolic and diastolic blood pressure to normal. The same patients were asked to withdraw sesame oil consumption for another 45 days, and the measurements were repeated at the end of withdrawal period. Withdrawal of sesame oil substitution brought back the initial blood pressure values. A significant reduction was noted in body weight and body mass index (BMI) upon sesame oil substitution. No significant alterations were observed in lipid profile except triglycerides. Plasma levels of sodium reduced while potassium elevated upon the substitution of sesame oil. Lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) decreased while the activities of superoxide dismutase (SOD), catalase (CAT), and the levels of vitamin C, vitamin E, Beta-carotene, and reduced glutathione (GSH) were increased. The results suggested that sesame oil as edible oil lowered blood pressure, decreased lipid peroxidation, and increased antioxidant status in hypertensive patients.
本研究旨在调查芝麻油对正在接受利尿剂（氢氯噻嗪）或β受体阻滞剂（阿替洛尔）降压治疗的高血压患者的影响。32名男性和18名年龄在35至60岁之间的女性患者被提供了芝麻油（Idhayam芝麻油），并被指示在45天内将其作为唯一的食用油使用。在基线时以及芝麻油替代45天后测量血压、人体测量学指标、血脂谱、脂质过氧化以及酶促和非酶促抗氧化剂。芝麻油替代使收缩压和舒张压降至正常。相同的患者被要求停止食用芝麻油45天，并在停药期结束时重复测量。停止芝麻油替代后，血压恢复到初始值。芝麻油替代后，体重和体重指数（BMI）显著降低。除甘油三酯外，血脂谱未观察到显著变化。芝麻油替代后，血浆钠水平降低而钾水平升高。脂质过氧化（硫代巴比妥酸反应性物质[TBARS]）降低，而超氧化物歧化酶（SOD）、过氧化氢酶（CAT）的活性以及维生素C、维生素E、β-胡萝卜素和还原型谷胱甘肽（GSH）的水平升高。结果表明，芝麻油作为食用油可降低高血压患者的血压、减少脂质过氧化并提高抗氧化状态。
