Sharma A, Kharb S, Chugh S N, Kakkar R, Singh G P
Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
Metabolism. 2000 Feb;49(2):160-2. doi: 10.1016/s0026-0495(00)91117-x.
The present study evaluates the presence of oxidative stress in the uncontrolled diabetic state. Glycemic control reduced the oxidative stress, but total normalization of the parameters of oxidative stress was not achieved, indicating continued oxidant injury despite optimal control of the diabetes. Vitamin E supplementation for 4 weeks in these patients further reduced the oxidative stress, suggesting that vitamin E supplementation might be helpful in reducing free-radical-induced oxidant injury.
本研究评估了未控制的糖尿病状态下氧化应激的存在情况。血糖控制降低了氧化应激，但氧化应激参数并未完全恢复正常，这表明尽管糖尿病得到了最佳控制，但仍存在持续的氧化损伤。在这些患者中补充维生素E 4周进一步降低了氧化应激，这表明补充维生素E可能有助于减少自由基诱导的氧化损伤。
