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本文引用的文献

1
Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes.长期心动过缓或心动过速家兔的钾通道亚基重塑：与延迟整流器差异变化相关的离散致心律失常后果
Circulation. 2006 Jan 24;113(3):345-55. doi: 10.1161/CIRCULATIONAHA.105.552968.
2
In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome.氟喹诺酮类抗菌药物诱发长QT综合征风险评估的体内实验方法
Eur J Pharmacol. 2004 Feb 20;486(2):189-200. doi: 10.1016/j.ejphar.2003.12.014.
3
Effects of three fluoroquinolones on QT interval in healthy adults after single doses.单次给药后三种氟喹诺酮类药物对健康成年人QT间期的影响。
Clin Pharmacol Ther. 2003 Apr;73(4):292-303. doi: 10.1016/s0009-9236(03)00009-2.
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Torsades de pointes associated with fluoroquinolones.与氟喹诺酮类药物相关的尖端扭转型室速。
Pharmacotherapy. 2002 May;22(5):663-8; discussion 668-72. doi: 10.1592/phco.22.8.663.33201.
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Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin.环丙沙星、氧氟沙星、左氧氟沙星、加替沙星和莫西沙星相关的尖端扭转型室速发生率。
Pharmacotherapy. 2001 Dec;21(12):1468-72. doi: 10.1592/phco.21.20.1468.34482.
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QTc interval prolongation associated with citalopram overdose: a case report and literature review.与西酞普兰过量相关的QTc间期延长：一例病例报告及文献综述
Clin Neuropharmacol. 2001 May-Jun;24(3):158-62. doi: 10.1097/00002826-200105000-00007.
7
Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects.单次口服莫西沙星（400毫克和800毫克）对健康受试者心室复极的影响。
Clin Pharmacol Ther. 2000 Dec;68(6):658-66. doi: 10.1067/mcp.2000.111482.
8
The safety profile of the fluoroquinolones.氟喹诺酮类药物的安全性概况。
Clin Ther. 2000 Jul;22(7):798-817; discussion 797. doi: 10.1016/S0149-2918(00)80053-3.
9
Quinolone-induced QT interval prolongation: a not-so-unexpected class effect.喹诺酮类药物引起的QT间期延长：一种并非完全意外的类效应。
J Antimicrob Chemother. 2000 May;45(5):557-9. doi: 10.1093/jac/45.5.557.
10
A method for estimating the probability of adverse drug reactions.一种估算药物不良反应概率的方法。
Clin Pharmacol Ther. 1981 Aug;30(2):239-45. doi: 10.1038/clpt.1981.154.

莫西沙星相关的尖端扭转型室速：一种罕见但可能致命的不良事件。

Torsade de pointes associated with moxifloxacin: a rare but potentially fatal adverse event.

作者信息

Altin T, Ozcan O, Turhan S, Ongun Ozdemir A, Akyurek O, Karaoguz R, Guldal M

机构信息

Ankara University School of Medicine, Ankara, Turkey.

出版信息

Can J Cardiol. 2007 Sep;23(11):907-8. doi: 10.1016/s0828-282x(07)70850-4.

DOI:10.1016/s0828-282x(07)70850-4
PMID:17876386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2651372/
Abstract

Torsade de pointes occuring due to a long QT interval is a rare but potentially fatal arrhythmia. Acquired long QT develops most commonly because of drugs that prolong ventricular repolarization. It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes. A patient with torsade de pointes risk factors (female sex, advanced age, extreme bradycardia and renal failure) who developed the condition on the fourth day of 400 mg/day of oral moxifloxacin treatment is presented. After the moxifloxacin was stopped, the corrected QT interval normalized and a permanent cardiac pacemaker was implanted. During 11 months of follow-up, arrhythmia did not recur.

摘要

由于长QT间期导致的尖端扭转型室速是一种罕见但可能致命的心律失常。获得性长QT最常见的原因是延长心室复极的药物。据报道，氟喹诺酮类抗菌药物可延长校正QT间期，但很少引起尖端扭转型室速。本文报告了一名有尖端扭转型室速危险因素（女性、高龄、极度心动过缓和肾衰竭）的患者，在口服莫西沙星400mg/天治疗的第4天出现了该病症。停用莫西沙星后，校正QT间期恢复正常，并植入了永久性心脏起搏器。在11个月的随访期间，心律失常未复发。