Badhu B, Baral N, Lamsal M, Das H, Dhital Badhu A
Department of Ophthalmology, B.P. Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal.
Southeast Asian J Trop Med Public Health. 2007 May;38(3):582-5.
Ascorbic acid in aqueous humor of the eye has a role as an antioxidant in delaying cataract formation. In a cross-sectional comparative study, ascorbic acid levels from aqueous humor and venous blood obtained from patients with cataracts in mountainous regions (1,300-2,000 meters) and subtropical lowlands (<100 meters) of Nepal were measured spectrophotometrically with the objective of comparing the levels of aqueous humor ascorbic acid in patients with cataracts from these two diverse geographical regions. Of 131 patients included in the study, 59 were from the mountainous region of Nepal (Group A) and 72 were from the subtropical lowlands (Group B). The mean (+/- SD) plasma ascorbic acid level (mg%) of the subjects in Group A was 0.65 (+/- 0.20) and Group B was 0.85 (+/- 0.31). The aqueous ascorbic acid levels ranged from 12-28 mg % (mean +/-SD = 17.5+/-4.52) and 14-50 mg % (mean +/-SD =23.47+/-8.66) in Groups A and B, respectively. The difference of the plasma and aqueous humor ascorbic acid levels between the two groups was statistically significant (p<0.01). The plasma and aqueous humor ascorbic acid levels in the people with cataracts from the mountainous region of Nepal were significantly lower than those from subtropical lowlands. This may be because of the effect of high altitude and ultraviolet rays on ascorbic acid metabolism.
眼房水中的抗坏血酸在延缓白内障形成方面具有抗氧化作用。在一项横断面比较研究中，采用分光光度法测量了尼泊尔山区（1300 - 2000米）和亚热带低地（<100米）白内障患者房水和静脉血中的抗坏血酸水平，目的是比较这两个不同地理区域白内障患者房水抗坏血酸水平。该研究纳入的131例患者中，59例来自尼泊尔山区（A组），72例来自亚热带低地（B组）。A组受试者血浆抗坏血酸水平（mg%）的均值（±标准差）为0.65（±0.20），B组为0.85（±0.31）。A组和B组房水抗坏血酸水平分别为12 - 28 mg%（均值±标准差 = 17.5±4.52）和14 - 50 mg%（均值±标准差 = 23.47±8.66）。两组间血浆和房水抗坏血酸水平差异具有统计学意义（p<0.01）。尼泊尔山区白内障患者的血浆和房水抗坏血酸水平显著低于亚热带低地患者。这可能是由于高海拔和紫外线对抗坏血酸代谢的影响。
