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物种对代谢综合征的影响:综述

Effect of species on the metabolic syndrome: A review.

作者信息

Mahdian Davood, Abbaszadeh-Goudarzi Kazem, Raoofi Amir, Dadashizadeh Ghazaleh, Abroudi Mina, Zarepour Elahe, Hosseinzadeh Hossein

机构信息

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Department of Pharmacology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

出版信息

Iran J Basic Med Sci. 2020 Nov;23(11):1374-1381. doi: 10.22038/ijbms.2020.42115.9957.

Abstract

The metabolic syndrome, a cluster of metabolic disorders, includes abdominal obesity, hypertension, dyslipidemia, and hyperglycemia leading to insulin resistance, development of diabetes mellitus, and cardiovascular diseases. For the treatment of metabolic syndrome, traditional herbal medicines such as frankincense or species have been used due to their anti-inflammatory, anti-oxidant, anti-obesity, antidiabetic, antihypertensive, and hypolipidemic properties. Based on the literature, published evidence up to 2020 about the therapeutic effects of species on the metabolic disorder among Medline, Scopus, and Google Scholar were precisely evaluated by keywords such as obesity, diabetes, hyperglycemia, hypertension, blood pressure, dyslipidemia, metabolic syndrome, frankincense, and Boswellia. According to the results, species have beneficial effects to control metabolic syndrome and its related disorders such as hyperglycemia, dyslipidemia, hypertension, obesity, diabetes, and its complications. species by reducing the resistance to insulin and restoring pancreatic beta cells decrease blood glucose. Also, species has antithrombotic and anticoagulant properties that regulate blood pressure. The anti-oxidant properties of species modulate the blood lipid profile via reducing TNF-α, IL-1β levels, and increasing the adiponectin level. The therapeutic and protective effects of species on metabolic disorders were remarkably confirmed regarding decreasing hyperglycemia, hyperlipidemia, hypertension, and obesity.

摘要

代谢综合征是一组代谢紊乱症候群,包括腹部肥胖、高血压、血脂异常和高血糖,可导致胰岛素抵抗、糖尿病的发生以及心血管疾病。对于代谢综合征的治疗,乳香等传统草药因其具有抗炎、抗氧化、抗肥胖、抗糖尿病、抗高血压和降血脂特性而被使用。基于文献,截至2020年,通过肥胖、糖尿病、高血糖、高血压、血压、血脂异常、代谢综合征、乳香和乳香属等关键词,对Medline、Scopus和谷歌学术搜索中已发表的关于乳香属对代谢紊乱治疗效果的证据进行了精确评估。根据结果,乳香属对控制代谢综合征及其相关疾病如高血糖、血脂异常、高血压、肥胖、糖尿病及其并发症具有有益作用。乳香属通过降低胰岛素抵抗和恢复胰腺β细胞来降低血糖。此外,乳香属具有抗血栓和抗凝特性,可调节血压。乳香属的抗氧化特性通过降低肿瘤坏死因子-α、白细胞介素-1β水平和增加脂联素水平来调节血脂谱。乳香属对代谢紊乱的治疗和保护作用在降低高血糖、高血脂、高血压和肥胖方面得到了显著证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/babd/7671425/6734710a24f7/IJBMS-23-1374-g001.jpg

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