Fransson Peter, Skiöld Beatrice, Horsch Sandra, Nordell Anders, Blennow Mats, Lagercrantz Hugo, Aden Ulrika
Magnetic Resonance Research Center, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15531-6. doi: 10.1073/pnas.0704380104. Epub 2007 Sep 18.
In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as systemwide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is currently unknown. Therefore, we used functional MRI to map patterns of resting-state activity in infants during sleep. We found five unique resting-states networks in the infant brain that encompassed the primary visual cortex, bilateral sensorimotor areas, bilateral auditory cortex, a network including the precuneus area, lateral parietal cortex, and the cerebellum as well as an anterior network that incorporated the medial and dorsolateral prefrontal cortex. These results suggest that resting-state networks driven by spontaneous signal fluctuations are present already in the infant brain. The potential link between the emergence of behavior and patterns of resting-state activity in the infant brain is discussed.
在没有任何明显任务执行的情况下，研究表明，在成人大脑中，自发的内在大脑活动表现为全脑范围的静息态网络。然而，目前尚不清楚人类大脑中通过神经元发育形成成人静息态活动模式的途径。因此，我们使用功能磁共振成像来绘制婴儿睡眠期间的静息态活动模式。我们在婴儿大脑中发现了五个独特的静息态网络，包括初级视觉皮层、双侧感觉运动区、双侧听觉皮层、一个包括楔前叶区域、外侧顶叶皮层和小脑的网络，以及一个包含内侧和背外侧前额叶皮层的前侧网络。这些结果表明，由自发信号波动驱动的静息态网络在婴儿大脑中已经存在。本文还讨论了婴儿大脑中行为出现与静息态活动模式之间的潜在联系。
