Fraguas Renerio, Iosifescu Dan V, Alpert Jonathan, Wisniewski Stephen R, Barkin Jennifer L, Trivedi Madhukar H, Rush A John, Fava Maurizio
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Harvard University, Boston, MA 02114, USA.
Psychosomatics. 2007 Sep-Oct;48(5):418-25. doi: 10.1176/appi.psy.48.5.418.
The authors conducted exploratory analyses to determine whether specific symptoms of major depressive disorder (MDD) are associated with cardiac disease in 4,041 outpatients at baseline in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. MDD was diagnosed with the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition; depressive symptoms were evaluated with the 30-item Inventory of Depressive Symptomatology, Clinician-Rated; and cardiac disease, with the Cumulative Illness Rating Scale. After adjustments for gender, age, ethnicity, education, and employment status, sympathetic arousal and early-morning insomnia were significantly associated with cardiac disease. Prospective studies are warranted to confirm these results.
作者进行了探索性分析，以确定在缓解抑郁的序贯治疗方案（STAR*D）研究中，4041名门诊患者基线时的重度抑郁症（MDD）特定症状是否与心脏病相关。MDD依据《精神疾病诊断与统计手册》第4版进行诊断；抑郁症状通过30项临床医生评定的抑郁症状量表进行评估；心脏病则通过累积疾病评定量表进行评估。在对性别、年龄、种族、教育程度和就业状况进行调整后，交感神经兴奋和早醒失眠与心脏病显著相关。有必要进行前瞻性研究以证实这些结果。
