Hanibuchi Masaki, Yano Seiji, Nishioka Yasuhiko, Miyoshi Takanori, Kondo Kazuya, Uehara Hisanori, Sone Saburo
Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima Graduate School, Tokushima, Japan.
J Med Invest. 2007 Aug;54(3-4):261-6. doi: 10.2152/jmi.54.261.
Lung cancer is the leading cause of cancer deaths in developed countries. Recently, autofluorescence bronchoscopy has been reported to improve the early detection of lung cancer in high-risk individuals. In the present study, we evaluated the efficacy of autofluorescence bronchoscopy for the early detection of bronchial premalignant and malignant lesions. From November 2000 through March 2004, 123 high-risk individuals (114 men and 9 women with a mean age of 68 years) were enrolled. Among 282 biopsy specimens, 93 (33.0%) were premalignant or malignant lesions. The sensitivity and negative predictive value for the detection of bronchial premalignant and malignant lesions were significantly higher with the addition of autofluorescence bronchoscopy than white light bronchoscopy alone. Moreover, the sensitivity for the detection of bronchial premalignant lesions was extremely higher with the addition of autofluorescence bronchoscopy than white light bronchoscopy alone, whereas there was no significant difference between autofluorescence bronchoscopy and white light bronchoscopy alone for the detection of non-malignant and malignant lesions. Autofluorescence bronchoscopy is a novel modality for the early detection of bronchial abnormality, especially for bronchial premalignant lesions.
肺癌是发达国家癌症死亡的主要原因。最近，有报道称自体荧光支气管镜检查可提高高危人群肺癌的早期检测率。在本研究中，我们评估了自体荧光支气管镜检查对支气管癌前病变和恶性病变早期检测的效果。从2000年11月至2004年3月，共纳入123名高危个体（114名男性和9名女性，平均年龄68岁）。在282份活检标本中，93份（33.0%）为癌前或恶性病变。与单纯白光支气管镜检查相比，联合使用自体荧光支气管镜检查对支气管癌前和恶性病变检测的敏感性和阴性预测值显著更高。此外，联合使用自体荧光支气管镜检查对支气管癌前病变检测的敏感性比单纯白光支气管镜检查极高，而对于非恶性和恶性病变的检测，自体荧光支气管镜检查与单纯白光支气管镜检查之间没有显著差异。自体荧光支气管镜检查是早期检测支气管异常的一种新方法，尤其是对于支气管癌前病变。
