Pogribny Igor P, Rusyn Ivan, Beland Frederick A
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
Environ Mol Mutagen. 2008 Jan;49(1):9-15. doi: 10.1002/em.20342.
Hepatocellular carcinoma, which is one of the most prevalent life-threatening human cancers, is showing an increased incidence worldwide. Recent evidence indicates that the development of hepatocellular carcinoma is associated with not only genetic alterations, but also with profound epigenetic changes. This review summarizes the current knowledge about epigenetic alterations during rodent hepatocarcinogenesis, considers the similarities and differences in epigenetic effects of genotoxic and non-genotoxic rodent liver carcinogens, and discusses the possible role of these effects in the causality of liver tumor development.
肝细胞癌是人类最常见的危及生命的癌症之一，在全球范围内其发病率呈上升趋势。最近的证据表明，肝细胞癌的发生不仅与基因改变有关，还与深刻的表观遗传变化有关。本综述总结了目前关于啮齿动物肝癌发生过程中表观遗传改变的知识，考虑了遗传毒性和非遗传毒性啮齿动物肝脏致癌物表观遗传效应的异同，并讨论了这些效应在肝肿瘤发生因果关系中的可能作用。
