Saisho Y, Butler A E, Meier J J, Monchamp T, Allen-Auerbach M, Rizza R A, Butler P C
Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, Los Angeles, CA 90095-7073, USA.
Clin Anat. 2007 Nov;20(8):933-42. doi: 10.1002/ca.20543.
Our aims were (1) by computed tomography (CT) to establish a population database for pancreas volume (parenchyma and fat) from birth to age 100 years, (2) in adults, to establish the impact of gender, obesity, and the presence or absence of type-2 diabetes on pancreatic volume (parenchyma and fat), and (3) to confirm the latter histologically from pancreatic tissue obtained at autopsy with a particular emphasis on whether pancreatic fat is increased in type-2 diabetes. We measured pancreas volume in 135 children and 1,886 adults (1,721 nondiabetic and 165 with type-2 diabetes) with no history of pancreas disease who had undergone abdominal CT scan between 2003 and 2006. Pancreas volume was computed from the contour of the pancreas on each CT image. In addition to total pancreas volume, parenchymal volume, fat volume, and fat/parenchyma ratio (F/P ratio) were determined by CT density. We also quantified pancreatic fat in autopsy tissue of 47 adults (24 nondiabetic and 23 with type-2 diabetes). During childhood and adolescence, the volumes of total pancreas, pancreatic parenchyma, and fat increase linearly with age. From age 20-60 years, pancreas volume reaches a plateau (72.4 +/- 25.8 cm(3) total; 44.5 +/- 16.5 cm(3) parenchyma) and then declines thereafter. In adults, total ( approximately 32%), parenchymal ( approximately 13%), and fat ( approximately 68%) volumes increase with obesity. Pancreatic fat content also increases with aging but is not further increased in type-2 diabetes. We provide lifelong population data for total pancreatic, parenchymal, and fat volumes in humans. Although pancreatic fat increases with aging and obesity, it is not increased in type-2 diabetes.
（1）通过计算机断层扫描（CT）建立一个从出生到100岁的胰腺体积（实质和脂肪）人群数据库；（2）在成年人中，确定性别、肥胖以及2型糖尿病的有无对胰腺体积（实质和脂肪）的影响；（3）通过尸检获得的胰腺组织进行组织学确认，特别关注2型糖尿病患者胰腺脂肪是否增加。我们测量了135名儿童和1886名成年人（1721名非糖尿病患者和165名2型糖尿病患者）的胰腺体积，这些人无胰腺疾病史，于2003年至2006年间接受了腹部CT扫描。胰腺体积根据每个CT图像上胰腺的轮廓计算得出。除了总胰腺体积外，还通过CT密度确定实质体积、脂肪体积和脂肪/实质比（F/P比）。我们还对47名成年人（24名非糖尿病患者和23名2型糖尿病患者）的尸检组织中的胰腺脂肪进行了定量分析。在儿童期和青春期，胰腺总体积、胰腺实质和脂肪体积随年龄呈线性增加。从20岁到60岁，胰腺体积达到平台期（总体积72.4±25.8 cm³；实质体积44.5±16.5 cm³），此后开始下降。在成年人中，总体积（约32%）、实质体积（约13%）和脂肪体积（约68%）随肥胖而增加。胰腺脂肪含量也随年龄增长而增加，但在2型糖尿病患者中并未进一步增加。我们提供了人类胰腺总体积、实质体积和脂肪体积的终生人群数据。虽然胰腺脂肪随衰老和肥胖而增加，但在2型糖尿病患者中并未增加。
