Grant Kathleen M, Kelley Stephanie Sinclair, Smith Lynette M, Agrawal Sangeeta, Meyer James R, Romberger Debra J
Substance Use Disorders Program, 116A4, Veterans Administration Nebraska Western Iowa Health Care System (Omaha site), 4101 Woolworth Avenue, Omaha, NE 68105, USA.
Alcohol. 2007 Aug;41(5):381-91. doi: 10.1016/j.alcohol.2007.03.011.
This is a double-blind placebo-controlled study of sustained-release bupropion as a smoking cessation aid in alcoholics undergoing treatment for their alcoholism. Participants (N=58) were enrolled within 1 week of entry into alcohol treatment from community and Veterans Affairs Substance Use Disorder programs. All participants received nicotine patch and were invited to attend a smoking cessation lecture and group. Cigarette smoking and alcohol outcomes were measured at 6 months. Bupropion when added to nicotine patch did not improve smoking outcomes. One third of participants on bupropion reported discontinuing the drug during weeks 1-4. Participants reported cigarette outcomes with nicotine patch that are similar to those seen in the general population. All study participants significantly reduced cigarette use. Comorbid affective disorder or antipersonality disorder did not affect outcomes. Alcohol outcomes were improved in those who discontinued cigarettes.
这是一项双盲安慰剂对照研究,旨在探讨缓释安非他酮作为一种戒烟辅助手段,帮助正在接受酒精成瘾治疗的酗酒者戒烟。参与者(N = 58)来自社区和退伍军人事务部物质使用障碍项目,在进入酒精治疗的1周内入组。所有参与者均接受尼古丁贴片,并被邀请参加戒烟讲座和小组活动。在6个月时测量吸烟和饮酒情况。安非他酮与尼古丁贴片联合使用时,并未改善吸烟效果。服用安非他酮的参与者中有三分之一报告在第1 - 4周内停药。参与者报告使用尼古丁贴片的吸烟情况与普通人群相似。所有研究参与者的吸烟量均显著减少。共病情感障碍或反社会人格障碍不影响结果。戒烟者的饮酒情况有所改善。