他汀类药物治疗与自身免疫性疾病：从蛋白质异戊二烯化到免疫调节
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation.
作者信息
Greenwood John, Steinman Lawrence, Zamvil Scott S
机构信息
Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
出版信息
Nat Rev Immunol. 2006 May;6(5):358-70. doi: 10.1038/nri1839.
Abstract
Statins have been prescribed extensively for their cholesterol-lowering properties and efficacy in cardiovascular disease. However, compelling evidence now exists that statins also have extensive immunomodulatory properties that operate independently of lipid lowering. Consequently, much attention has been directed towards their potential as therapeutic agents for the treatment of autoimmune disease. Modulation of post-translational protein prenylation seems to be a key mechanism by which statins alter immune function. In this Review, the effect of statin therapy on immune function, and how this relates to the pathogenesis of autoimmune disease, is reviewed alongside current opinion of what the key biological targets of statins are.
摘要
他汀类药物因其降低胆固醇的特性及在心血管疾病中的疗效而被广泛应用。然而，目前有确凿证据表明，他汀类药物还具有广泛的免疫调节特性，且这种特性独立于降脂作用。因此，人们对其作为治疗自身免疫性疾病的治疗药物的潜力给予了极大关注。调节翻译后蛋白质异戊二烯化似乎是他汀类药物改变免疫功能的关键机制。在本综述中，我们回顾了他汀类药物治疗对免疫功能的影响，以及这与自身免疫性疾病发病机制的关系，同时也阐述了目前关于他汀类药物关键生物学靶点的观点。
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