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Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.复杂N-聚糖的数量和分支程度协同调节细胞增殖和分化。
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Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motif.对具有β3GT或β4GT基序的糖基转移酶进行全面的酶学表征。
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Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans.小鼠CD4+和CD8+ T淋巴细胞的激活会导致N-连接聚糖的显著重塑。
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Evanescent-field fluorescence-assisted lectin microarray: a new strategy for glycan profiling.倏逝场荧光辅助凝集素微阵列：一种聚糖分析的新策略。
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CD28 T cell costimulatory receptor function is negatively regulated by N-linked carbohydrates.CD28共刺激受体功能受到N-连接碳水化合物的负调控。
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Glycan-dependent leukocyte adhesion and recruitment in inflammation.炎症中聚糖依赖性白细胞粘附与募集
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A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression.一种参与人类血型I抗原表达的新型I分支β-1,6-N-乙酰葡糖胺基转移酶。
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Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions.簇、束、阵列和晶格：凝集素-糖介导的细胞相互作用的新机制。
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Oligosaccharide specificity of galectins: a search by frontal affinity chromatography.半乳糖凝集素的寡糖特异性：通过前沿亲和色谱法进行的研究
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糖蛋白上的多乳糖胺影响淋巴细胞和巨噬细胞激活的基础水平。

Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation.

作者信息

Togayachi Akira, Kozono Yuko, Ishida Hiroyasu, Abe Sumie, Suzuki Nami, Tsunoda Yuki, Hagiwara Kozue, Kuno Atsushi, Ohkura Takashi, Sato Nobuo, Sato Takashi, Hirabayashi Jun, Ikehara Yuzuru, Tachibana Kouichi, Narimatsu Hisashi

机构信息

Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Central-2 OSL, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan.

出版信息

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15829-34. doi: 10.1073/pnas.0707426104. Epub 2007 Sep 21.

DOI:10.1073/pnas.0707426104
PMID:17890318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2000437/
Abstract

beta1,3-N-acetylglucosaminyltransferase 2 (beta3GnT2) is a polylactosamine synthase that synthesizes a backbone structure of carbohydrate structures onto glycoproteins. Here we generated beta3GnT2-deficient (beta3GnT2(-/-)) mice and showed that polylactosamine on N-glycans was markedly reduced in their immunological tissues. In WT mice, polylactosamine was present on CD28 and CD19, both known immune costimulatory molecules. However, polylactosamine levels on these molecules were reduced in beta3GnT2(-/-) mice. beta3GnT2(-/-) T cells lacking polylactosamine were more sensitive to the induction of intracellular calcium flux on stimulation with anti-CD3epsilon/CD28 and proliferated more strongly than T cells from WT mice. beta3GnT2(-/-) B cells also showed hyperproliferation on BCR stimulation. Macrophages from beta3GnT2(-/-) mice had higher cell surface CD14 levels and enhanced responses to endotoxin. These results indicate that polylactosamine on N-glycans is a putative immune regulatory factor presumably suppressing excessive responses during immune reactions.

摘要

β1,3-N-乙酰葡糖胺基转移酶2（β3GnT2）是一种多乳糖胺合酶，可在糖蛋白上合成碳水化合物结构的骨架结构。在此，我们培育出了β3GnT2基因敲除（β3GnT2(-/-)）小鼠，并发现其免疫组织中N-聚糖上的多乳糖胺显著减少。在野生型小鼠中，多乳糖胺存在于CD28和CD19这两种已知的免疫共刺激分子上。然而，在β3GnT2(-/-)小鼠中，这些分子上的多乳糖胺水平降低。缺乏多乳糖胺的β3GnT2(-/-) T细胞在用抗CD3ε/CD28刺激时对细胞内钙流的诱导更敏感，并且比野生型小鼠的T细胞增殖更强。β3GnT2(-/-) B细胞在BCR刺激时也表现出过度增殖。β3GnT2(-/-)小鼠的巨噬细胞具有更高的细胞表面CD14水平，并且对内毒素的反应增强。这些结果表明，N-聚糖上的多乳糖胺是一种假定的免疫调节因子，可能在免疫反应期间抑制过度反应。