Gram J, Bollerslev J, Nielsen H K, Junker P
Department of Medical Endocrinology, Odense University Hospital, Denmark.
Acta Endocrinol (Copenh). 1991 Dec;125(6):609-13. doi: 10.1530/acta.0.1250609.
To investigate bone collagen metabolism during vitamin D treatment, 15 healthy males (aged 28-45 years, median 34) were treated orally with calcitriol, 2 micrograms daily for 7 days and followed for a total of 2 weeks. The serum concentration of calcitriol rose markedly (median difference and 95% confidence limits: 49% (5-82), p less than 0.005) during treatment, whereas serum levels of calcidiol, and calcium remained unchanged. The serum level of procollagen type I C-terminal propeptide rose 15% (7-33, p less than 0.003), whereas no alterations were observed concerning serum procollagen type III N-terminal propeptide, and serum hyaluronan. The serum concentration of osteocalcin rose concomitantly (26% (12-45), p less than 0.003). All values returned to baseline levels within seven days after the treatment week. The serum levels of osteocalcin and procollagen type I C-terminal propeptide were positively correlated (rs = 0.71, p less than 0.004) during the study. Serum procollagen type I C-terminal propeptide and serum osteocalcin did not correlate with serum procollagen type III N-terminal propeptide or serum hyaluronan either at baseline or after treatment. It is concluded that a short course of calcitriol administration to healthy males stimulates the biosynthesis of bone-related matrix proteins. By contrast, connective tissue components of predominantly extraosseous origin are not affected.
为研究维生素D治疗期间的骨胶原代谢情况，对15名健康男性（年龄28 - 45岁，中位数34岁）口服骨化三醇进行治疗，每日2微克，持续7天，并总共随访2周。治疗期间骨化三醇的血清浓度显著升高（中位数差异及95%置信区间：49%（5 - 82），p<0.005），而血清骨化二醇和钙水平保持不变。I型前胶原C端前肽的血清水平升高了15%（7 - 33，p<0.003），而血清III型前胶原N端前肽和血清透明质酸未观察到变化。骨钙素的血清浓度随之升高（26%（12 - 45），p<0.003）。在治疗周后的7天内，所有值均恢复至基线水平。在研究期间，骨钙素和I型前胶原C端前肽的血清水平呈正相关（rs = 0.71，p<0.004）。血清I型前胶原C端前肽和血清骨钙素在基线时或治疗后与血清III型前胶原N端前肽或血清透明质酸均无相关性。结论是，对健康男性短期给予骨化三醇可刺激骨相关基质蛋白的生物合成。相比之下，主要源于骨外的结缔组织成分未受影响。
