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黄斑、猴子、模型、年龄相关性黄斑变性与衰老

Maculas, monkeys, models, AMD and aging.

作者信息

Dawson William W, Dawson Judyth C, Lake Kenneth P, Gonzalez-Martinez Janis

机构信息

Department of Ophthalmology, University of Florida, 1600 SW Archer Road, Rm: M119, Gainesville, FL 32610-0284, USA.

出版信息

Vision Res. 2008 Feb;48(3):360-5. doi: 10.1016/j.visres.2007.08.006. Epub 2007 Sep 24.

DOI:10.1016/j.visres.2007.08.006
PMID:17892891
Abstract

Age related macular degeneration (AMD) signs may be found reliably in monkeys (Macaca mulatta) bred selectively in Florida after 14 generations of inbreeding in a closed colony at the University of Puerto Rico. Progression, ultrastructure and functional losses are parallel to those found in humans.

摘要

在波多黎各大学一个封闭群落中经过14代近亲繁殖后在佛罗里达州选择性培育的猕猴(恒河猴)中,可以可靠地发现与年龄相关的黄斑变性(AMD)体征。其进展、超微结构和功能丧失与人类中发现的情况相似。

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