Engel H M, Dawson W W, Ulshafer R J, Hines M W, Kessler M J
Department of Ophthalmology, College of Medicine, University of Florida, Gainesville.
Ophthalmologica. 1988;196(3):143-50. doi: 10.1159/000309891.
In the hope of identifying an animal model for age-related macular degeneration (AMD) we undertook a pilot investigation of aged rhesus monkeys. Twenty-nine monkeys from a seminatural colony were examined at the Caribbean Primate Research Center. Macular drusen were found in 74% of the monkey eyes. Alterations of the retinal pigment epithelium within the macula were noted in 45% of the eyes. Fluorescein angiography in selected animals revealed window defects consistent with drusen. None of this sample showed the exudative form of AMD or disciform scarring. One typical monkey underwent special studies including measurement of visual resolution by electrophysiological study of the retinal and visual cortex. Application of human criteria to this animal supported the diagnosis of early AMD. Histopathologic study of one eye by transmission electron microscopy confirmed the presence of drusen with nearly identical ultrastructural features to those found in the human pigment epithelium in AMD.
为了确定年龄相关性黄斑变性（AMD）的动物模型，我们对老年恒河猴进行了一项初步研究。在加勒比灵长类动物研究中心对来自半自然群体的29只猴子进行了检查。在74%的猴眼中发现了黄斑玻璃膜疣。在45%的眼睛中注意到黄斑区内视网膜色素上皮的改变。对选定动物进行的荧光素血管造影显示出与玻璃膜疣一致的窗样缺损。该样本中没有一只显示出渗出性AMD或盘状瘢痕形成。一只典型的猴子接受了特殊研究，包括通过视网膜和视觉皮层的电生理研究来测量视觉分辨率。将人类标准应用于该动物支持早期AMD的诊断。通过透射电子显微镜对一只眼睛进行组织病理学研究证实了玻璃膜疣的存在，其超微结构特征与AMD患者人类色素上皮中发现的特征几乎相同。
