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我们如何才能实现伤口的氧平衡?

How might we achieve oxygen balance in wounds?

作者信息

Davis Paul J

机构信息

Insense Ltd., Colworth Science Park, Sharnbrook, Bedford, UK.

出版信息

Int Wound J. 2007 Sep;4 Suppl 3(Suppl 3):18-24. doi: 10.1111/j.1742-481X.2007.00384.x.

Abstract

This paper describes the mechanism and physiological relevance of a new kind of oxygenating wound care technology, designed to deliver 'oxygen balance'. It provides a continuous, controlled delivery of dissolved oxygen over an appropriate time scale, at the same time as providing all the required basics of wound care. Even though it is initially perceived as a simple dressing, it is an advanced, active biochemical process contained in a dressing structure, using the enzyme glucose oxidase to capture and transport oxygen from the atmosphere. With this technology, it is proposed that oxygen balance can be defined by relating the levels of achievable oxygenation to the cellular and biochemical activities required to bring about optimal wound healing.

摘要

本文描述了一种新型的氧合伤口护理技术的机制及生理相关性,该技术旨在实现“氧平衡”。它能在适当的时间范围内持续、可控地输送溶解氧,同时提供伤口护理所需的所有基本要素。尽管它最初被视为一种简单的敷料,但它是一种包含在敷料结构中的先进的、活跃的生化过程,利用葡萄糖氧化酶从大气中捕获和运输氧气。通过这项技术,有人提出,可以通过将可实现的氧合水平与实现最佳伤口愈合所需的细胞和生化活动联系起来,来定义氧平衡。

相似文献

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How might we achieve oxygen balance in wounds?我们如何才能实现伤口的氧平衡?
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本文引用的文献

1
Best practice recommendations for preparing the wound bed: update 2006.伤口床准备的最佳实践建议:2006年更新版
Adv Skin Wound Care. 2007 Jul;20(7):390-405; quiz 406-7. doi: 10.1097/01.ASW.0000280200.65883.fd.
3
Oxygen-dependent differentiation of human keratinocytes.人角质形成细胞的氧依赖性分化
J Invest Dermatol. 2007 Feb;127(2):354-61. doi: 10.1038/sj.jid.5700522. Epub 2006 Sep 14.
5
Wound bed preparation and a brief history of TIME.伤口床准备及TIME简史
Int Wound J. 2004 Apr;1(1):19-32. doi: 10.1111/j.1742-481x.2004.00008.x.
6
Hypoxia regulates macrophage functions in inflammation.缺氧在炎症中调节巨噬细胞功能。
J Immunol. 2005 Nov 15;175(10):6257-63. doi: 10.4049/jimmunol.175.10.6257.
8
Oxygen in wound healing--more than a nutrient.伤口愈合中的氧气——不仅仅是一种营养物质。
World J Surg. 2004 Mar;28(3):294-300. doi: 10.1007/s00268-003-7400-2. Epub 2004 Feb 17.

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