因切尔诺贝利核电站事故遭受电离辐射的慢性淋巴细胞白血病患者——以免疫球蛋白重链基因分析为重点
Chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chernobyl NPP accident--with focus on immunoglobulin heavy chain gene analysis.
作者信息
Abramenko Iryna, Bilous Nadia, Chumak Anatoliy, Davidova Ekaterina, Kryachok Iryna, Martina Zoya, Nechaev Stanislav, Dyagil Iryna, Bazyka Dmytriy, Bebeshko Vladimir
机构信息
Research Centre for Radiation Medicine, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
出版信息
Leuk Res. 2008 Apr;32(4):535-45. doi: 10.1016/j.leukres.2007.08.013. Epub 2007 Sep 25.
Clinical data and immunoglobulin variable heavy chain (IgVH) gene configuration were analyzed in 47 CLL patients, exposed to ionizing radiation (IR) due to Chernobyl NPP accident, and 141 non-exposed patients. Clean-up workers of the second quarter of 1986 (n=19) were picked out as separate group with the highest number of unmutated cases (94.4%), increased usage of IgVH1-69 (33.3%) and IgVH3-21 (16.7%) genes, high frequency of secondary solid tumors (6 cases) and Richter transformation (4 cases). These preliminary data suggest that CLL in the most suffered contingent due to Chernobyl NPP accident might have some specific features.
对47例因切尔诺贝利核电站事故遭受电离辐射（IR）的慢性淋巴细胞白血病（CLL）患者以及141例未受辐射的患者进行了临床数据和免疫球蛋白重链可变区（IgVH）基因构型分析。1986年第二季度的清理工人（n = 19）被单独列为一组，该组未突变病例数最多（94.4%），IgVH1-69（33.3%）和IgVH3-21（16.7%）基因的使用率增加，继发性实体瘤（6例）和 Richter 转化（4例）的频率较高。这些初步数据表明，因切尔诺贝利核电站事故受灾最严重的人群中的CLL可能具有一些特定特征。
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