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[切尔诺贝利事故后接受辐射的慢性淋巴细胞白血病患者实体瘤的发病率]

[Incidence of solid tumors in patients with chronic lymphocytic leukemia exposed to radiation after Chernobyl accident].

出版信息

Ter Arkh. 2011;83(10):18-22.

Abstract

AIM

To study incidence of solid tumors in patients who developed chronic lymphocytic leukemia (CLL) after exposure to ionizing radiation after the Chernobyl accident.

MATERIAL AND METHODS

After analysis of data on all CLL male patients living in Kiev registered in the National Cancer Register of Ukraine in 1991-2008, these patients were divided into two groups. Group 1 consisted of 56 Chernobyl rescuers exposed to ionizing radiation, group 2 - of 684 patients without history of Chernobyl-related radiation.

RESULTS

Solid tumors were detected in 14 cases in group 1 and 74 cases in group 2 (p = 0.001). Risk to develop solid tumors in group 1 was significantly higher (OR 3.29 in 95% CI from 1.61 to 6.62).

CONCLUSION

The conclusion made needs further verification on wider data base.

摘要

目的

研究切尔诺贝利事故后暴露于电离辐射下发生慢性淋巴细胞白血病(CLL)的患者实体瘤的发病率。

材料与方法

在分析1991 - 2008年乌克兰国家癌症登记处登记的所有居住在基辅的男性CLL患者的数据后,将这些患者分为两组。第1组由56名暴露于电离辐射的切尔诺贝利救援人员组成,第2组由684名无切尔诺贝利相关辐射史的患者组成。

结果

第1组中有14例检测到实体瘤,第2组中有74例(p = 0.001)。第1组发生实体瘤的风险显著更高(95%置信区间为1.61至6.62时,比值比为3.29)。

结论

所得出的结论需要在更广泛的数据库上进一步验证。

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