Held L I
Department of Biological Sciences, Texas Tech University, Lubbock 79409.
Bioessays. 1991 Dec;13(12):633-40. doi: 10.1002/bies.950131203.
The 5000 bristles that protrude from the cuticle of a Drosophila adult function as either mechanosensors or chemosensors, and they are arranged in surprisingly intricate patterns. Development of the patterns appears to involve five stages: (1) establishment of a coordinate system of 'positional information'; (2) partitioning of the epidermis into areas where bristles either can or cannot originate; (3) selection of one or more bristle mother cells within each permissible area; (4) suppression of bristle development in the neighborhood of each mother cell; and (5) differentiation of the mother cell to produce four or more descendant cells, each of which forms part of the bristle apparatus. Some of the genes that control these events participate in more than one stage, and others play key roles in seemingly unrelated developmental pathways, including embryonic neurogenesis, body segmentation, and sex determination.
从果蝇成虫表皮突出的5000根刚毛起着机械传感器或化学传感器的作用，并且它们以惊人复杂的模式排列。这些模式的形成似乎涉及五个阶段：（1）建立“位置信息”的坐标系；（2）将表皮划分为刚毛可以或不可以起源的区域；（3）在每个允许区域内选择一个或多个刚毛母细胞；（4）抑制每个母细胞附近的刚毛发育；（5）母细胞分化产生四个或更多的后代细胞，每个细胞形成刚毛器官的一部分。一些控制这些事件的基因参与不止一个阶段，而其他基因在看似不相关的发育途径中起关键作用，包括胚胎神经发生、身体分段和性别决定。
