Bernateck Michael, Rolke Roman, Birklein Frank, Treede Rolf-Detlef, Fink Matthias, Karst Matthias
Department of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany.
Anesth Analg. 2007 Oct;105(4):1148-51, table of contents. doi: 10.1213/01.ane.0000278867.24601.a0.
Cytokines, particularly tumor necrosis factor-alpha, may play an important role in the mediation of mechanical hyperalgesia and autonomic signs in complex regional pain syndrome 1. We performed an IV regional block with low-dose administration of the tumor necrosis factor-alpha antibody, infliximab, in a patient with typical clinical signs of complex regional pain syndrome 1 (moderate pain, edema, hyperhidrosis, elevated skin temperature compared with the contralateral side). A significant improvement of clinical variables was observed 24 h after infliximab treatment. Almost complete remission was reached within 8 wk, but sensory signs improved only after 6 mo. No adverse events were observed.
细胞因子，尤其是肿瘤坏死因子-α，可能在复杂性区域疼痛综合征1的机械性痛觉过敏和自主神经症状的介导中发挥重要作用。我们对一名具有复杂性区域疼痛综合征1典型临床症状（中度疼痛、水肿、多汗、与对侧相比皮肤温度升高）的患者进行了低剂量肿瘤坏死因子-α抗体英夫利昔单抗的静脉区域阻滞。英夫利昔单抗治疗24小时后观察到临床变量有显著改善。8周内几乎完全缓解，但感觉症状仅在6个月后有所改善。未观察到不良事件。
