Saleem Muhammad, Ali Muhammad Shaiq, Hussain Shafqat, Jabbar Abdul, Ashraf Muhammad, Lee Yong Sup
Pharmaceutical Research Center, PCSIR Labs. Complex, 75280, Karachi, Pakistan.
Nat Prod Rep. 2007 Oct;24(5):1142-52. doi: 10.1039/b607254m. Epub 2007 Mar 22.
In the search for novel and bioactive molecules for drug discovery, marine-derived natural resources are becoming an important research area. Over 15 marine-derived secondary metabolites are currently in human clinical trials. Terrestrial fungi have produced many therapeutically significant molecules. However, the potential of marine fungi has only been investigated to a limited extent. This review article contains 103 marine-derived fungal metabolites and 77 references.
在寻找用于药物发现的新型生物活性分子的过程中,海洋来源的自然资源正成为一个重要的研究领域。目前有超过15种海洋来源的次生代谢产物正处于人体临床试验阶段。陆生真菌已经产生了许多具有治疗意义的分子。然而,海洋真菌的潜力仅在有限的程度上得到了研究。这篇综述文章包含103种海洋来源的真菌代谢产物和77篇参考文献。