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Natural history of sub-retinal triamcinolone acetonide deposition after triamcinolone-assisted vitrectomy.

作者信息

Sampangi Raju, Venkatesh Pradeep, Garg Sat Pal

机构信息

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, 110029, New Delhi, India.

出版信息

Int Ophthalmol. 2008 Oct;28(5):359-62. doi: 10.1007/s10792-007-9136-8. Epub 2007 Sep 26.

DOI:10.1007/s10792-007-9136-8
PMID:17898938
Abstract

PURPOSE

To describe the natural course of subretinal triamcinolone acetonide (TA) deposition after a TA-assisted vitrectomy for retinal detachment.

METHODS

Observational case series.

RESULTS

TA deposition was observed between the neurosensory retina and retinal pigment epithelium in the macular area at the conclusion of vitreoretinal surgery in three patients with retinal detachment. On follow up, TA granules gradually decreased over the next 2 weeks and resolved completely by 3 weeks. Two months after the operation, the retina was observed to be successfully attached and no ophthalmoscopic or functional damage was observed.

CONCLUSION

As no apparent clinically detectable adverse effect was found in the three cases that demonstrated subretinal deposition of TA we opine that active surgical maneuvers to remove the same are not warranted during surgery.

摘要

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本文引用的文献

1
Evaluation of subretinal triamcinolone acetonide in patients with exudative age-related macular degeneration.
J Ocul Pharmacol Ther. 2007 Feb;23(1):46-53. doi: 10.1089/jop.2006.0092.
2
Evaluation of the toxicity of subretinal triamcinolone acetonide in the rabbit.兔眼视网膜下注射曲安奈德的毒性评估。
Retina. 2006 Sep;26(7):811-7. doi: 10.1097/01.iae.0000244255.22406.2f.
3
The use of subretinal triamcinolone acetonide in the management of neovascular age-related macular degeneration: a pilot study.曲安奈德玻璃体腔注射治疗新生血管性年龄相关性黄斑变性的初步研究
Can J Ophthalmol. 2005 Oct;40(5):573-84. doi: 10.1016/S0008-4182(05)80049-3.
4
Submacular deposition of triamcinolone acetonide after triamcinolone-assisted vitrectomy.曲安奈德辅助玻璃体切除术后曲安奈德在黄斑下的沉积。
Am J Ophthalmol. 2003 Feb;135(2):243-6. doi: 10.1016/s0002-9394(02)01917-7.
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Accidental subretinal injection of triamcinolone acetonide.
Ophthalmic Surg Lasers. 1998 Nov;29(11):935-8.