Andrejevic-Blant Snezana, Kosmahl Markus, Sipos Bence, Klöppel Günter
Institute of Pathology, Faculty of Medicine and Biology, University of Lausanne, Lausanne, Switzerland.
Virchows Arch. 2007 Nov;451(5):863-9. doi: 10.1007/s00428-007-0512-6. Epub 2007 Sep 27.
For a long time, intraductal tumors of the pancreas were neglected because they were misdiagnosed as mucinous cystadenocarcinoma, ordinary ductal adenocarcinoma, or chronic pancreatitis. Only in recent years have they been recognized as clinical and pathological entities. Most common are the intraductal papillary-mucinous neoplasms. Although they show an adenoma-carcinoma sequence, they have proved to have a more favorable prognosis than ductal adenocarcinoma, when resected in a preinvasive state. Recently, it has become clear that they constitute a heterogeneous group with at least four subtypes. Their stratification reveals that the various intraductal papillary-mucinous neoplasm subtypes have different biological properties with different prognostic implications.
长期以来，胰腺导管内肿瘤一直被忽视，因为它们被误诊为黏液性囊腺癌、普通导管腺癌或慢性胰腺炎。直到近年来，它们才被确认为临床和病理实体。最常见的是导管内乳头状黏液性肿瘤。尽管它们呈现腺瘤-癌序列，但已证明在癌前状态下切除时，其预后比导管腺癌更有利。最近，很明显它们构成了一个至少有四种亚型的异质性群体。它们的分层显示，各种导管内乳头状黏液性肿瘤亚型具有不同的生物学特性和不同的预后意义。
