T(1Gd)作为1.5T和3.0T场强下的dGEMRIC指数的适用性。

Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T.

作者信息

Williams Ashley, Mikulis Brandon, Krishnan Nitya, Gray Martha, McKenzie Charlie, Burstein Deborah

机构信息

Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.

出版信息

Magn Reson Med. 2007 Oct;58(4):830-4. doi: 10.1002/mrm.21376.

DOI:10.1002/mrm.21376

PMID:17899599

Abstract

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is based on the theory that Gd-DTPA(2-) will distribute in inverse relation to cartilage glycosaminoglycan (GAG). T(1Gd) (T(1) after penetration of a 0.2 mmol/kg dose of Gd-DTPA(2-)) has been used as the dGEMRIC index, although (1/T(1Gd)-1/T(1o)) should be more representative of Gd-DTPA(2-) concentration (where T(1o) = T(1) before contrast). T(1o) and T(1Gd) were measured in 20 volunteers at both 1.5T and 3T and the correlation between the metrics of T(1Gd) and (1/T(1Gd)-1/T(1o)) was calculated. There was a high correlation coefficient between the two metrics at both field strengths, with R = 0.94, 0.93, and 0.90 for central medial femur, posterior medial femur, and medial tibia, respectively, at 1.5T and 0.87, 0.94, 0.96 at 3T. In all cases P < 0.0001. Therefore, these data suggest that, for native cartilage, the current practice of measuring T(1Gd) (but not also T(1o)) is adequate at both 1.5T and 3T.

摘要

延迟钆增强磁共振成像（dGEMRIC）基于这样的理论，即钆喷酸葡胺（Gd-DTPA(2-)）将与软骨糖胺聚糖（GAG）呈反比分布。尽管（1/T(1Gd)-1/T(1o)）应更能代表Gd-DTPA(2-)浓度（其中T(1o)=注射造影剂前的T(1)），但T(1Gd)（注射0.2 mmol/kg剂量的Gd-DTPA(2-)后的T(1)）已被用作dGEMRIC指标。在20名志愿者中于1.5T和3T场强下测量了T(1o)和T(1Gd)，并计算了T(1Gd)指标与（1/T(1Gd)-1/T(1o)）之间的相关性。在两个场强下，这两个指标之间均有较高的相关系数，在1.5T时，股骨内侧中央、股骨内侧后部和胫骨内侧的相关系数R分别为0.94、0.93和0.90，在3T时分别为0.87、0.94和0.96。在所有情况下，P<0.0001。因此，这些数据表明，对于天然软骨，目前测量T(1Gd)（但不测量T(1o)）的做法在1.5T和3T场强下都是合适的。