Deng Xiaodong, Eriksson Mats
Umeå Plant Science Center, Umeå University, SE-901 87 Umeå, Sweden.
Eukaryot Cell. 2007 Nov;6(11):2163-7. doi: 10.1128/EC.00324-07. Epub 2007 Sep 28.
FOX1 encodes an iron deficiency-induced ferroxidase involved in a high-affinity iron uptake system. Mutagenesis analysis of the FOX1 promoter identified two separate iron-responsive elements, FeRE1 (CACACG) and FeRE2 (CACGCG), between positions -87 and -82 and between positions -65 and -60, respectively, and both are needed for induced FOX1 expression under conditions of iron deficiency.
FOX1编码一种参与高亲和力铁摄取系统的缺铁诱导的铁氧化酶。对FOX1启动子的诱变分析确定了两个独立的铁反应元件,FeRE1(CACACG)和FeRE2(CACGCG),分别位于-87至-82位和-65至-60位之间,并且在缺铁条件下诱导FOX1表达两者都是必需的。