基于器官清除率、循环和分形概念的高级药代动力学模型。
Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts.
作者信息
Pang K Sandy, Weiss Michael, Macheras Panos
机构信息
Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada M5S 3M2.
出版信息
AAPS J. 2007 Jun 29;9(2):E268-83. doi: 10.1208/aapsj0902030.
Abstract
Three advanced models of pharmacokinetics are described. In the first class are physiologically based pharmacokinetic models based on in vitro data on transport and metabolism. The information is translated as transporter and enzyme activities and their attendant heterogeneities into liver and intestine models. Second are circulatory models based on transit time distribution and plasma concentration time curves. The third are fractal models for nonhomogeneous systems and non-Fickian processes are presented. The usefulness of these pharmacokinetic models, with examples, is compared.
摘要
本文描述了三种先进的药代动力学模型。第一类是基于转运和代谢体外数据的生理药代动力学模型。这些信息被转化为转运体和酶的活性及其伴随的异质性，并纳入肝脏和肠道模型。第二类是基于转运时间分布和血浆浓度-时间曲线的循环模型。第三类是针对非均匀系统和非菲克过程的分形模型。文中通过实例比较了这些药代动力学模型的实用性。
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