Wada Shun-ichi, Yasui Yumiko, Hitomi Teppei, Tanaka Reiko
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
J Nat Prod. 2007 Oct;70(10):1605-10. doi: 10.1021/np070104o. Epub 2007 Oct 2.
The MeOH extract of the bark of Picea jezoensis var. jezoensis was found to show scavenging activity for the DPPH radical. Bioassay-guided fractionation led to the isolation of two new flavonostilbenes named jezonocinols A ( 1) and B ( 2) and one nor-flavonostilbene named jezonocinol C ( 3) together with six known phenolic compounds. Their structures were elucidated by spectroscopic methods, and the absolute configurations of jezonocinols A ( 1) and B ( 2) were determined by Mosher's method, CD, and NOESY data.
研究发现，红皮云杉树皮的甲醇提取物对DPPH自由基具有清除活性。通过生物活性导向的分离方法，分离得到了两种新的黄酮芪类化合物，分别命名为红皮云杉醇A（1）和B（2），以及一种去甲黄酮芪类化合物红皮云杉醇C（3），同时还得到了六种已知的酚类化合物。通过光谱方法对它们的结构进行了阐明，并通过Mosher法、圆二色光谱（CD）和核Overhauser效应光谱（NOESY）数据确定了红皮云杉醇A（1）和B（2）的绝对构型。
