狭叶长叶书带蕨的成分及其生物活性。

Constituents of Vittaria anguste-elongata and their biological activities.

作者信息

Wu Pei-Lin, Hsu Yu-Lin, Zao Chen-Wei, Damu Amooru G, Wu Tian-Shung

机构信息

Department of Chemistry, National Cheng Kung University, Tainan, 701, Taiwan, Republic of China.

出版信息

J Nat Prod. 2005 Aug;68(8):1180-4. doi: 10.1021/np050060o.

DOI:10.1021/np050060o

PMID:16124757

Abstract

Twelve new compounds, vittarin-A (1), -B (2), -C (3), -D (4), -E (5), -F (6), 3-O-acetylniduloic acid (7), ethyl 3-O-acetylniduloate (8), methyl 4-O-coumaroylquinate (9), vittarilide-A (10), and -B (11), and vittariflavone (12), as well as 20 known compounds have been isolated from the whole plant of Vittaria anguste-elongata. The structures of these compounds were determined by spectroscopic and chemical transformation methods. 5,7-Dihydroxy-3',4',5'-trimethoxyflavone (18) displayed moderate cytotoxicity against human lung carcinoma and central nervous system carcinoma cell lines with inhibition of 89 and 61% at a concentration of 58 microM, respectively. Vittarilide-A (10) and -B (11) and ethyl 4-O-caffeoylquinate (14) exhibited moderate DPPH radical scavenging activity with IC50 values of 91, 290, and 234 microM, respectively.

摘要

从狭叶长叶书带蕨全草中分离得到了12个新化合物，分别为书带蕨素-A（1）、-B（2）、-C（3）、-D（4）、-E（5）、-F（6）、3-O-乙酰鸟巢酸（7）、3-O-乙酰鸟巢酸乙酯（8）、4-O-香豆酰奎宁酸甲酯（9）、书带蕨内酯-A（10）、-B（11）以及书带蕨黄酮（12），还有20个已知化合物。这些化合物的结构通过光谱和化学转化方法得以确定。5,7-二羟基-3',4',5'-三甲氧基黄酮（18）对人肺癌和中枢神经系统癌细胞系显示出中等程度的细胞毒性，在浓度为58微摩尔时，抑制率分别为89%和61%。书带蕨内酯-A（10）、-B（11）以及4-O-咖啡酰奎宁酸乙酯（14）表现出中等程度的DPPH自由基清除活性，IC50值分别为91、290和234微摩尔。