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秀丽隐杆线虫衰老的遗传学

Genetics of aging in Caenorhabditis elegans.

作者信息

Antebi Adam

机构信息

Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.

出版信息

PLoS Genet. 2007 Sep;3(9):1565-71. doi: 10.1371/journal.pgen.0030129.

DOI:10.1371/journal.pgen.0030129
PMID:17907808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1994694/
Abstract

A dissection of longevity in Caenorhabditis elegans reveals that animal life span is influenced by genes, environment, and stochastic factors. From molecules to physiology, a remarkable degree of evolutionary conservation is seen.

摘要

对秀丽隐杆线虫寿命的剖析表明，动物的寿命受到基因、环境和随机因素的影响。从分子层面到生理层面，都可以看到显著程度的进化保守性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19b/1994694/f32942731878/pgen.0030129.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19b/1994694/f32942731878/pgen.0030129.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19b/1994694/f32942731878/pgen.0030129.g001.jpg

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Aging Cell. 2007 Aug;6(4):483-8. doi: 10.1111/j.1474-9726.2007.00303.x. Epub 2007 Jun 8.
2
Two neurons mediate diet-restriction-induced longevity in C. elegans.两个神经元介导了秀丽隐杆线虫中饮食限制诱导的长寿。
Nature. 2007 May 31;447(7144):545-9. doi: 10.1038/nature05904.
3
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.PHA-4/Foxa介导饮食限制诱导的秀丽隐杆线虫寿命延长。
Heliyon. 2024 Aug 2;10(15):e35556. doi: 10.1016/j.heliyon.2024.e35556. eCollection 2024 Aug 15.
4
Jujubae Fructus extract prolongs lifespan and improves stress tolerance in Caenorhabditis elegans dependent on DAF-16/SOD-3.大枣提取物通过依赖 DAF-16/SOD-3 延长秀丽隐杆线虫的寿命并提高其应激耐受力。
Sci Rep. 2024 Jun 14;14(1):13713. doi: 10.1038/s41598-024-64045-0.
5
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age.长寿相关遗传变异相互作用作为 85 岁以上人群生存预测因子的作用。
Mech Ageing Dev. 2024 Jun;219:111926. doi: 10.1016/j.mad.2024.111926. Epub 2024 Mar 13.
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Regulation of defective mitochondrial DNA accumulation and transmission in by the programmed cell death and aging pathways.通过程序性细胞死亡和衰老途径调节 中线粒体 DNA 积累和传递的缺陷。
Elife. 2023 Oct 2;12:e79725. doi: 10.7554/eLife.79725.
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