• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

关于[具体植物名称]中皂苷的抗氧化和抗衰老作用的研究。 需注意，原文中“in.”后面缺少具体内容，以上是补充完整植物名称后的译文，以便符合正常表达。若要严格按照原文翻译，可译为“关于……中皂苷的抗氧化和抗衰老作用的研究” 。

Research on the anti-oxidant and anti-aging effects of saponins in .

作者信息

Huang Yaqi, Wang Yetong, Deng Jia, Gao Sijie, Qiu Jiakang, He Jiawei, Yang Tong, Tan Nianhua, Cheng Shaowu, Song Zhenyan

机构信息

School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China.

Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China.

出版信息

Heliyon. 2024 Aug 2;10(15):e35556. doi: 10.1016/j.heliyon.2024.e35556. eCollection 2024 Aug 15.

DOI:10.1016/j.heliyon.2024.e35556
PMID:39170193
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11336756/
Abstract

Oxidative stress and its impact on aging are critical areas of research. Natural anti-oxidants, such as saponins found in , hold promise as potential clinical interventions against aging. In this study, we utilized the nematode model organism, , to investigate the pharmacological effects of saponins (PKS) on antioxidation and anti-aging. The results demonstrated a significant anti-aging biological activity associated with PKS. Through experiments involving lifespan and stress, lipofuscin, q-PCR, and ROS measurement, we found that PKS effectively mitigated aging-related processes. Furthermore, the mechanism underlying these anti-aging effects was linked to the SKN-1 signaling pathway. PKS increased the nuclear localization of the SKN-1 transcription factor, leading to the up-regulation of downstream anti-oxidant genes, such as gst-4 and sod-3, and a substantial reduction in intracellular ROS levels within the nematode. In conclusion, our study sheds light on the anti-oxidant and anti-aging properties of PKS in . This research not only contributes to understanding the biological mechanisms involved but also highlights the potential therapeutic applications of these natural compounds in combating aging-related processes.

摘要

氧化应激及其对衰老的影响是关键的研究领域。天然抗氧化剂，如存在于[具体来源未提及]中的皂苷，有望成为对抗衰老的潜在临床干预手段。在本研究中，我们利用线虫模式生物[线虫名称未提及]来研究[具体名称未提及]皂苷（PKS）的抗氧化和抗衰老药理作用。结果表明PKS具有显著的抗衰老生物活性。通过涉及寿命和应激、脂褐素、定量聚合酶链反应（q-PCR）以及活性氧（ROS）测量的实验，我们发现PKS有效减轻了与衰老相关的过程。此外，这些抗衰老作用的潜在机制与SKN-1信号通路有关。PKS增加了SKN-1转录因子的核定位，导致下游抗氧化基因如gst-4和sod-3的上调，并使线虫体内细胞内ROS水平大幅降低。总之，我们的研究揭示了PKS在[线虫名称未提及]中的抗氧化和抗衰老特性。这项研究不仅有助于理解其中涉及的生物学机制，还突出了这些天然化合物在对抗与衰老相关过程中的潜在治疗应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/34b9da5aefee/mmcfigs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/27c09828e3b7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/4de852cddacd/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/b0562d486573/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/8e5f41fa861b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/4d58f5919bec/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/34b9da5aefee/mmcfigs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/27c09828e3b7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/4de852cddacd/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/b0562d486573/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/8e5f41fa861b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/4d58f5919bec/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fde/11336756/34b9da5aefee/mmcfigs1.jpg

相似文献

1
Research on the anti-oxidant and anti-aging effects of saponins in .关于[具体植物名称]中皂苷的抗氧化和抗衰老作用的研究。 需注意，原文中“in.”后面缺少具体内容，以上是补充完整植物名称后的译文，以便符合正常表达。若要严格按照原文翻译，可译为“关于……中皂苷的抗氧化和抗衰老作用的研究” 。
Heliyon. 2024 Aug 2;10(15):e35556. doi: 10.1016/j.heliyon.2024.e35556. eCollection 2024 Aug 15.
2
Anti-Aging in of Polysaccharides from Hua.黄花草多糖的抗衰老作用。
Molecules. 2024 Mar 13;29(6):1276. doi: 10.3390/molecules29061276.
3
Polygonati Rhizoma Polysaccharide Prolongs Lifespan and Healthspan in .黄精多糖延长. 的寿命和健康跨度。
Molecules. 2023 Feb 27;28(5):2235. doi: 10.3390/molecules28052235.
4
Responses of bitter melon saponins to oxidative stress and aging via the IIS pathway linked with sir-2.1 and hlh-30.苦瓜皂苷通过与sir-2.1和hlh-30相关的胰岛素/胰岛素样生长因子信号（IIS）途径对氧化应激和衰老的反应
J Food Biochem. 2022 Dec;46(12):e14456. doi: 10.1111/jfbc.14456. Epub 2022 Oct 13.
5
Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract.美登木皂苷提取物可增强秀丽隐杆线虫的抗压和抗衰老活性。
Eur J Nutr. 2021 Jun;60(4):1819-1832. doi: 10.1007/s00394-020-02338-6. Epub 2020 Aug 29.
6
extract exhibited antioxidant effects to promote longevity and stress resistance in .提取物表现出抗氧化作用，可促进 长寿和抗应激能力。
Food Funct. 2023 Oct 30;14(21):9743-9754. doi: 10.1039/d3fo02578k.
7
Alpiniae oxyphylla fructus extract promotes longevity and stress resistance of DAF-16 and SKN-1.益智仁提取物可促进DAF-16和SKN-1的寿命延长及抗应激能力。
Front Pharmacol. 2022 Nov 24;13:1034515. doi: 10.3389/fphar.2022.1034515. eCollection 2022.
8
Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways.厚鳞柯叶提取物通过 DAF-16/FoxO 和 SKN-1/Nrf-2 信号通路延长秀丽隐杆线虫寿命并增强其抗氧化应激能力。
Phytomedicine. 2019 Nov;64:153061. doi: 10.1016/j.phymed.2019.153061. Epub 2019 Jul 31.
9
SKN-1 is involved in combination of apple peels and blueberry extracts synergistically protecting against oxidative stress in Caenorhabditis elegans.SKN-1 参与了苹果皮和蓝莓提取物的联合作用，协同保护秀丽隐杆线虫免受氧化应激。
Food Funct. 2020 Jun 24;11(6):5409-5419. doi: 10.1039/d0fo00891e.
10
Nobiletin Delays Aging and Enhances Stress Resistance of .川陈皮素延缓衰老并增强. 的应激抵抗能力。
Int J Mol Sci. 2020 Jan 4;21(1):341. doi: 10.3390/ijms21010341.

引用本文的文献

1
Zuogui and Yougui pills extend lifespan and improve ageing biomarkers via kaempferol-mediated mitophagy in Caenorhabditis elegans.左归丸和右归丸通过山奈酚介导的线粒体自噬延长秀丽隐杆线虫的寿命并改善衰老生物标志物。
Biogerontology. 2025 Aug 27;26(5):172. doi: 10.1007/s10522-025-10317-9.
2
The pivotal regulatory role of the FEV-SLC7A11 axis in ferroptosis elucidates the anti-aging mechanism of β-sitosterol in a cross-species study.在一项跨物种研究中，FEV-SLC7A11轴在铁死亡中的关键调节作用阐明了β-谷甾醇的抗衰老机制。
Front Pharmacol. 2025 Aug 7;16:1600489. doi: 10.3389/fphar.2025.1600489. eCollection 2025.
3
, , and as a Functional Food Formula: Cognitive Enhancement via Modulation of Hippocampal Neuroinflammation and Neuroprotection in Sleep-Restricted Mice.

本文引用的文献

1
The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans.SKN-1/Nrf2 对秀丽隐杆线虫寿命的代谢贡献。
Metabolomics. 2023 Jun 8;19(6):58. doi: 10.1007/s11306-023-02022-w.
2
Research progress in steroidal saponins from the genus Polygonatum: Chemical components, biosynthetic pathways and pharmacological effects.玉竹属甾体皂苷的研究进展：化学组成、生物合成途径及药理作用。
Phytochemistry. 2023 Sep;213:113731. doi: 10.1016/j.phytochem.2023.113731. Epub 2023 May 26.
3
Yolk-deprived secure brood size at the expense of competitive fitness.
, , 以及 作为一种功能性食品配方：通过调节睡眠受限小鼠海马神经炎症和神经保护作用实现认知增强。
Foods. 2025 Mar 22;14(7):1103. doi: 10.3390/foods14071103.
牺牲竞争适应度换取缺乏蛋黄的安全窝卵数。
Life Sci Alliance. 2023 Apr 14;6(6). doi: 10.26508/lsa.202201675. Print 2023 Jun.
4
Polygonati Rhizoma Polysaccharide Prolongs Lifespan and Healthspan in .黄精多糖延长. 的寿命和健康跨度。
Molecules. 2023 Feb 27;28(5):2235. doi: 10.3390/molecules28052235.
5
Polygonati Rhizoma with the homology of medicine and food: A review of ethnopharmacology, botany, phytochemistry, pharmacology and applications.药食同源中药材——黄精：民族药理学、植物学、植物化学、药理学及应用研究进展。
J Ethnopharmacol. 2023 Jun 12;309:116296. doi: 10.1016/j.jep.2023.116296. Epub 2023 Feb 24.
6
Zhuyeqing liquor promotes longevity through enhancing stress resistance via regulation of SKN-1 and HSF-1 transcription factors in Caenorhabditis elegans.竹叶青酒通过调控秀丽隐杆线虫中的SKN-1和HSF-1转录因子增强抗逆性来促进长寿。
Exp Gerontol. 2023 Apr;174:112131. doi: 10.1016/j.exger.2023.112131. Epub 2023 Mar 8.
7
Optimization of the Ultrasonic-Assisted Extraction Technology of Steroidal Saponins from Collett & Hemsl and Evaluating Its Quality Planted in Different Areas.优化超声辅助提取 Collett & Hemsl 甾体皂苷的技术，并评估其在不同地区种植的质量。
Molecules. 2022 Feb 22;27(5):1463. doi: 10.3390/molecules27051463.
8
Advances in Mechanism Research on in Prevention and Treatment of Diabetes.糖尿病防治的机制研究进展
Front Pharmacol. 2022 Feb 8;13:758501. doi: 10.3389/fphar.2022.758501. eCollection 2022.
9
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives.氧化应激与人类疾病和衰老：分子机制与展望。
Cells. 2022 Feb 5;11(3):552. doi: 10.3390/cells11030552.
10
Thunb extract extended the lifespan and healthspan of DAF-16/SIR-2.1/SKN-1.旋覆花提取物延长了 DAF-16/SIR-2.1/SKN-1 的寿命和健康寿命。
Food Funct. 2021 Sep 20;12(18):8774-8786. doi: 10.1039/d1fo01908b.