Epstein Leonard H, Temple Jennifer L, Neaderhiser Brad J, Salis Robbert J, Erbe Richard W, Leddy John J
Department of Pediatrics, University at Buffalo, State University of New York, Buffalo, NY 14214-3000, USA.
Behav Neurosci. 2007 Oct;121(5):877-86. doi: 10.1037/0735-7044.121.5.877.
The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with the TaqI A1 allele. Energy intake was greater for individuals high in food reinforcement and greatest in those high in food reinforcement with the TaqI A1 allele. No effect of the DAT1 genotype was observed. These data show that individual differences in food reinforcement may be important for obesity and that the DRD2 genotype may interact with food reinforcement to influence energy intake.
作者对29名18至40岁的肥胖者和45名非肥胖者测量了食物强化、多巴胺D2受体（DRD2）基因和多巴胺转运体（DAT1）基因的多态性以及实验室能量摄入量。肥胖者的食物强化程度高于非肥胖者，尤其是携带TaqI A1等位基因的肥胖个体。食物强化程度高的个体能量摄入量更大，而携带TaqI A1等位基因且食物强化程度高的个体能量摄入量最大。未观察到DAT1基因型的影响。这些数据表明，食物强化方面的个体差异可能对肥胖很重要，并且DRD2基因型可能与食物强化相互作用以影响能量摄入。
