膦甲酸钠对爱泼斯坦-巴尔病毒抗原表达和病毒产生的差异效应。
Differential effect of phosphonoacetic acid on the expression of Epstein-Barr viral antigens and virus production.
作者信息
Nyormoi O, Thorley-Lawson D A, Elkington J, Strominger J L
出版信息
Proc Natl Acad Sci U S A. 1976 May;73(5):1745-8. doi: 10.1073/pnas.73.5.1745.
Abstract
The effects of phosphonoacetic acid on cell growth, expression of Epstein-Barr virus antigens, and virus production in human and marmoset lymphoblastoid cell lines have been studied. The drug had no significant effect at concentrations up to 100 mug/ml on cell growth or total cell DNA synthesis. Higher doses induced not only a drastic decrease in DNA synthesis and cell grwoth, but also a dramatic cell enlargement. Immunofluorescence studies showed that greater than or equal to 30 mug/ml of phosphonoacetic acid inhibited viral capsid antigen synthesis without affecting the expression of the nuclear antigen or the spontaneous and 5-iodo-2'-deoxyuridine-induced early antigens. Production of transforming Epstein-Barr virus was also blocked.
摘要
已经研究了膦甲酸对人和狨猴淋巴母细胞系中细胞生长、爱泼斯坦-巴尔病毒抗原表达及病毒产生的影响。该药物在浓度高达100μg/ml时对细胞生长或总细胞DNA合成无显著影响。更高剂量不仅导致DNA合成和细胞生长急剧下降，还导致细胞显著增大。免疫荧光研究表明，膦甲酸浓度大于或等于30μg/ml时可抑制病毒衣壳抗原合成，而不影响核抗原的表达以及自发和5-碘-2'-脱氧尿苷诱导的早期抗原的表达。转化型爱泼斯坦-巴尔病毒的产生也受到阻断。
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