脂肪来源干细胞与软骨形成

Adipose-derived stem cells and chondrogenesis.

作者信息

Wei Y, Sun X, Wang W, Hu Y

机构信息

Institute of Orthopaedics and Traumatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China.

出版信息

Cytotherapy. 2007;9(8):712-6. doi: 10.1080/14653240701620596. Epub 2007 Oct 4.

DOI:10.1080/14653240701620596

PMID:17917888

Abstract

Cartilage has only a very limited capacity to renew its original structure. Stem cells have been used to repair damaged cartilage, and recent studies have indicated that stem cells from adipose tissue are attractive cell sources that have the capacity of multipotentiality to differentiate into osteogenic, chondrogenic, myogenic, neurogenic and endothelial cells. Adipose-derived stem cells (ASC) have unique characteristics compared with stem cells from BM. At present, ASC have been studied to promote chondrogenesis. This review discusses the application of ASC to cartilage formation.

摘要

软骨更新其原始结构的能力非常有限。干细胞已被用于修复受损软骨，最近的研究表明，脂肪组织来源的干细胞是有吸引力的细胞来源，具有多能性，可分化为成骨细胞、软骨细胞、肌细胞、神经细胞和内皮细胞。与骨髓来源的干细胞相比，脂肪来源的干细胞（ASC）具有独特的特性。目前，已对ASC促进软骨形成进行了研究。本文综述了ASC在软骨形成中的应用。