免疫突触和亲和突触处的细胞黏附分子与肌动蛋白细胞骨架
Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses.
作者信息
Dustin Michael L
机构信息
Program in Molecular Pathogenesis, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, United States.
出版信息
Curr Opin Cell Biol. 2007 Oct;19(5):529-33. doi: 10.1016/j.ceb.2007.08.003. Epub 2007 Oct 17.
Abstract
The immunological synapse is a stable adhesive junction between a polarized immune effector cell and an antigen-bearing cell. Immunological synapses are often observed to have a striking radial symmetry in the plane of contact with a prominent central cluster of antigen receptors surrounded by concentric rings of adhesion molecules and actin-rich projections. There is a striking similarity between the radial zones of the immunological synapse and the dynamic actinomyosin modules employed by migrating cells. Breaking the symmetry of an immunological synapse generates a moving adhesive junction that can be defined as a kinapse, which facilitates signal integration by immune cells while moving over the surface of antigen-presenting cells.
摘要
免疫突触是极化的免疫效应细胞与携带抗原的细胞之间的稳定黏附连接。免疫突触在与抗原受体的突出中央簇接触的平面上通常呈现出显著的径向对称性，周围是黏附分子和富含肌动蛋白的突起形成的同心环。免疫突触的径向区域与迁移细胞所采用的动态肌动蛋白-肌球蛋白模块之间存在显著相似性。打破免疫突触的对称性会产生一个可定义为运动突触（kinapse）的移动黏附连接，其在抗原呈递细胞表面移动时促进免疫细胞的信号整合。
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