Döbereiner Hans-Günther, Dubin-Thaler Benjamin J, Hofman Jake M, Xenias Harry S, Sims Tasha N, Giannone Grégory, Dustin Michael L, Wiggins Chris H, Sheetz Michael P
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Phys Rev Lett. 2006 Jul 21;97(3):038102. doi: 10.1103/PhysRevLett.97.038102. Epub 2006 Jul 20.
We have monitored active movements of the cell circumference on specifically coated substrates for a variety of cells including mouse embryonic fibroblasts and T cells, as well as wing disk cells from fruit flies. Despite having different functions and being from multiple phyla, these cell types share a common spatiotemporal pattern in their normal membrane velocity; we show that protrusion and retraction events are organized in lateral waves along the cell membrane. These wave patterns indicate both spatial and temporal long-range periodic correlations of the actomyosin gel.
我们已经监测了多种细胞（包括小鼠胚胎成纤维细胞、T细胞以及果蝇的翅盘细胞）在特殊涂层基质上细胞周长的活跃运动。尽管这些细胞类型具有不同的功能且来自多个门，但它们在正常膜速度方面具有共同的时空模式；我们发现，突出和回缩事件沿细胞膜以横向波的形式组织起来。这些波型表明了肌动球蛋白凝胶在空间和时间上的长程周期性关联。
