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新生儿高甘油三酯血症:产前-产时胎儿应激的新指标?

Neonatal hypertriglyceridemia: a new index of antepartum-intrapartum fetal stress?

作者信息

Andersen G E, Friis-Hansen B

出版信息

Acta Paediatr Scand. 1976 May;65(3):369-74. doi: 10.1111/j.1651-2227.1976.tb04899.x.

DOI:10.1111/j.1651-2227.1976.tb04899.x
PMID:179271
Abstract

The 95th percentile value of cord serum triglyceride concentration in 82 consecutively live born infants was found to be 0.79 mmol/l. This level was arbitrarily used to define neonatal hypertriglyceridemia. A comparison between 78 normotriglyceridemic and 61 hypertriglyceridemic newborn infants showed a significant association between elevated cord serum triglyceride concentration and insufficiency of the placenta, fetal bradycardia, meconium-stained amniotic fluid and one-minute Apgar score less than or equal to 7. A significantly (p less than 0.001) greater number of infants with one or several of these four factors, indicating antepartum and/or intrapartum fetal stress were found to be hypertriglyceridemic at birth. This finding suggests that estimation of cord serum triglyceride which is easy and inexpensive might be of value for a more complete evaluation of the newborn infant, and can serve as a supplement to the Apgar Score system.

摘要

在82例连续活产婴儿中,脐血甘油三酯浓度的第95百分位数为0.79 mmol/l。该水平被随意用来定义新生儿高甘油三酯血症。对78例正常甘油三酯血症新生儿和61例高甘油三酯血症新生儿进行比较,结果显示脐血甘油三酯浓度升高与胎盘功能不全、胎儿心动过缓、羊水胎粪污染以及1分钟阿氏评分小于或等于7之间存在显著关联。发现有这四个因素中的一个或几个(表明产前和/或产时胎儿应激)的婴儿在出生时高甘油三酯血症的比例显著更高(p<0.001)。这一发现表明,脐血甘油三酯的测定简便且廉价,可能有助于对新生儿进行更全面的评估,可作为阿氏评分系统的补充。

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Neonatal hypertriglyceridemia: a new index of antepartum-intrapartum fetal stress?新生儿高甘油三酯血症:产前-产时胎儿应激的新指标?
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引用本文的文献

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Altered Cord Blood Lipid Concentrations Correlate with Birth Weight and Doppler Velocimetry of Fetal Vessels in Human Fetal Growth Restriction Pregnancies.在人类胎儿生长受限妊娠中,改变的脐血脂质浓度与胎儿血管的出生体重和多普勒流速有关。
Cells. 2022 Oct 2;11(19):3110. doi: 10.3390/cells11193110.
2
A report of high triglyceride level in cord blood of Iranian newborns.伊朗新生儿脐带血中甘油三酯水平偏高的报告。
Int J Prev Med. 2013 Jul;4(7):755-60.
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Plasma lipids and blood glucose in infants of toxemic mothers.患毒血症母亲所生婴儿的血浆脂质与血糖
Indian J Pediatr. 1989 May-Jun;56(3):403-8. doi: 10.1007/BF02722312.