韦尼克-科尔萨科夫脑病
Wernicke-Korsakoff encephalopathy.
作者信息
Pearce J M S
机构信息
Emeritus Consultant Neurologist, Department of Neurology, Hull Royal Infirmary and Hull York Medical School, Hull, UK.
出版信息
Eur Neurol. 2008;59(1-2):101-4. doi: 10.1159/000109580. Epub 2007 Oct 11.
Wernicke described the clinical features of three patients, including two alcoholics, suffering from confusion, ataxia and ophthalmoplegia in whom pathologically he found 'polioencephalitis haemorrhagica superioris'. Korsakoff's doctoral thesis related similar findings but expanded the confabulation and amnesic elements, relating them to alcoholism. This paper, which summarises the salient aspects of the syndrome, discusses their work and shows important earlier descriptions by James Jackson, (1822) Samuel Wilks (1868) and Charles Gayet (1875).
韦尼克描述了三名患者的临床特征，其中包括两名酗酒者，他们患有意识模糊、共济失调和眼肌麻痹，他在病理学上发现他们患有“上出血性脑灰质炎”。科萨科夫的博士论文涉及类似的发现，但扩展了虚构和失忆的因素，并将它们与酗酒联系起来。本文总结了该综合征的主要方面，讨论了他们的研究工作，并展示了詹姆斯·杰克逊（1822年）、塞缪尔·威尔克斯（1868年）和查尔斯·加耶（1875年）更早的重要描述。
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