Wang Heyao, Zhang Jiali, Gao Chunsheng, Zhu Ying, Wang Chen, Zheng Wenjie
Department of Pharmacology, Beijing Chaoyang Hospital affiliated with Capital University of Medical Sciences, Beijing, China.
Eur J Pharmacol. 2007 Dec 22;577(1-3):162-9. doi: 10.1016/j.ejphar.2007.08.023. Epub 2007 Aug 25.
Allergic rhinitis is one of the most common chronic diseases. There are a number of effective therapeutic options for allergic rhinitis patients, such as intranasal corticosteroids. How to avoid the adverse effects of these traditional medicines has come to public attention and started the search for effective and safe medicine. We used BALB/c mice with experimental allergic rhinitis, and determined that levamisole delivered locally (intranasal, i.n.) could attenuate early-phase inflammatory response, decrease histamine, suppress edema and eosinophil infiltration, and diminish the ovalbumin-specific serum IgE level. Detailed analysis of cytokine gene expression showed that levamisole can decrease IL-4, IL-5 and IL-13 mRNA and increase IL-12, IL-18 and IFN-gamma mRNA. Levamisole showed analogous effects of down-regulating Th2 cytokines with budesonide and distinct up-regulating effects on Th1 cytokines gene expression. Our findings offer potential options for allergic rhinitis therapy.
过敏性鼻炎是最常见的慢性疾病之一。对于过敏性鼻炎患者有多种有效的治疗选择，如鼻内用皮质类固醇。如何避免这些传统药物的不良反应已引起公众关注，并开始寻找有效且安全的药物。我们使用患有实验性过敏性鼻炎的BALB/c小鼠，确定局部（鼻内，i.n.）给予左旋咪唑可减轻早期炎症反应、降低组胺水平、抑制水肿和嗜酸性粒细胞浸润，并降低卵清蛋白特异性血清IgE水平。对细胞因子基因表达的详细分析表明，左旋咪唑可降低IL-4、IL-5和IL-13 mRNA水平，并增加IL-12、IL-18和IFN-γ mRNA水平。左旋咪唑显示出与布地奈德类似的下调Th2细胞因子的作用，以及对Th1细胞因子基因表达的明显上调作用。我们的研究结果为过敏性鼻炎治疗提供了潜在的选择。
