Breddemann André, Läer Stephanie, Schmidt Klaus G, Harjes Malte, Adam Rüdiger, Ludwig Amei, Niehues Tim, Schneider Dominik T
Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University of Düsseldorf, Germany.
Herpes. 2007 Sep;14(2):41-4.
Lymphotropic herpesviruses such as human herpesvirus type 6 (HHV-6) have enhanced pathogenicity in some immunocompromised hosts, such as transplant recipients and HIV-infected patients. The clinical relevance of HHV-6 infections in cancer patients undergoing conventional cytotoxic therapy is undetermined, however. Here we report on a 10-month-old boy with an anaplastic astrocytoma, who acquired an HHV-6 variant B infection during chemotherapy. HHV-6B infection caused or triggered severe gastrointestinal inflammation with intractable diarrhoea and failure to thrive over several months. The clinical symptoms were associated with pronounced (CD4) lymphopenia and a marked increase in serum immunoglobulin A levels. After unsuccessful therapy with ganciclovir and foscarnet, combined antiviral and anti-inflammatory treatment with cidofovir and prednisolone controlled the HHV-6 infection and enabled resolution of clinical symptoms.
亲淋巴性疱疹病毒，如人类疱疹病毒6型（HHV-6），在一些免疫功能低下的宿主中具有增强的致病性，如移植受者和HIV感染患者。然而，HHV-6感染在接受传统细胞毒性疗法的癌症患者中的临床相关性尚不确定。在此，我们报告一名10个月大患有间变性星形细胞瘤的男孩，他在化疗期间感染了HHV-6 B型变体。HHV-6 B感染导致或引发了严重的胃肠道炎症，伴有数月的顽固性腹泻和发育不良。临床症状与明显的（CD4）淋巴细胞减少和血清免疫球蛋白A水平显著升高有关。在用更昔洛韦和膦甲酸钠治疗失败后，联合使用西多福韦和泼尼松龙进行抗病毒和抗炎治疗控制了HHV-6感染，并使临床症状得以缓解。
