狨猴大脑中成年神经发生减少先于老年出现。
Diminished adult neurogenesis in the marmoset brain precedes old age.
作者信息
Leuner Benedetta, Kozorovitskiy Yevgenia, Gross Charles G, Gould Elizabeth
机构信息
Department of Psychology, Princeton University, Princeton, NJ 08544, USA.
出版信息
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17169-73. doi: 10.1073/pnas.0708228104. Epub 2007 Oct 16.
With aging there is a decline in the number of newly generated neurons in the dentate gyrus of the hippocampus. In rodents and tree shrews, this age-related decrease in neurogenesis is evident long before the animals become aged. No previous studies have investigated whether primates exhibit a similar decline in hippocampal neurogenesis with aging. To investigate this possibility, young to middle aged adult common marmosets (Callithrix jacchus) were injected with BrdU and perfused 3 weeks later. The number of newly generated cells in the subgranular zone/granule cell layer of the dentate gyrus was significantly lower in older animals and decreased linearly with age. A similar age-related decline in new cells was observed in the subventricular zone but not in the hilar region of the dentate gyrus. These data demonstrate that a substantial decrease in neurogenesis occurs before the onset of old age in the adult marmoset brain, suggesting the possibility that similar alterations occur in the human brain.
随着年龄增长，海马齿状回中新生神经元的数量会减少。在啮齿动物和树鼩中，这种与年龄相关的神经发生减少早在动物进入老年之前就很明显。以前没有研究调查过灵长类动物是否也会随着年龄增长出现类似的海马神经发生减少。为了研究这种可能性，对幼年到中年的普通狨猴（Callithrix jacchus）注射溴脱氧尿苷（BrdU），并在3周后进行灌注。老年动物齿状回颗粒下区/颗粒细胞层中新生细胞的数量显著减少，并且随年龄呈线性下降。在脑室下区也观察到了类似的与年龄相关的新细胞减少，但在齿状回的门区未观察到。这些数据表明，成年狨猴大脑在进入老年之前神经发生就会大幅减少，这表明人类大脑可能也会发生类似的变化。
Zotero 插件