大豆与益生菌或益生元食品的饮食组合可显著降低轻度高胆固醇血症患者的总胆固醇和低密度脂蛋白胆固醇。
Dietary combination of soy with a probiotic or prebiotic food significantly reduces total and LDL cholesterol in mildly hypercholesterolaemic subjects.
作者信息
Larkin T A, Astheimer L B, Price W E
机构信息
Department of Biomedical Science, University of Wollongong, Wollongong, New South Wales, Australia.
出版信息
Eur J Clin Nutr. 2009 Feb;63(2):238-45. doi: 10.1038/sj.ejcn.1602910. Epub 2007 Oct 17.
OBJECTIVE
We hypothesized that a dietary combination of soy with either a probiotic (yoghurt) or a prebiotic (resistant starch) would result in enhanced lipid-lowering effects compared with a control soy diet, possibly via improvements in isoflavone bioavailability.
SUBJECTS
Mildly hypercholesterolaemic subjects (men and post-menopausal women) older than 45 years were recruited via the local media. Thirty-six subjects commenced the study; five withdrew.
RESULTS
Soy+probiotic significantly decreased total cholesterol (4.7+/-2.0%; P=0.038) and soy+prebiotic significantly decreased total and low-density lipoprotein cholesterol (5.5+/-1.6%; P=0.003 and 7.3+/-2.2%; P=0.005, respectively). The bioavailabilities of daidzein, genistein or equol were not affected by probiotic or prebiotic consumption or associated with lipid changes.
CONCLUSION
Dietary combination of soy with either a probiotic or a prebiotic resulted in significant lipid lowering, not related to isoflavone bioavailability.
目的
我们推测，与对照大豆饮食相比，大豆与益生菌（酸奶）或益生元（抗性淀粉）的饮食组合可能会通过改善异黄酮的生物利用度而增强降脂效果。
受试者
通过当地媒体招募了45岁以上的轻度高胆固醇血症受试者（男性和绝经后女性）。36名受试者开始研究；5人退出。
结果
大豆+益生菌显著降低总胆固醇（4.7±2.0%；P=0.038），大豆+益生元显著降低总胆固醇和低密度脂蛋白胆固醇（分别为5.5±1.6%；P=0.003和7.3±2.2%；P=0.005）。大豆苷元、染料木黄酮或雌马酚的生物利用度不受益生菌或益生元摄入的影响，也与血脂变化无关。
结论
大豆与益生菌或益生元的饮食组合可显著降低血脂，与异黄酮的生物利用度无关。
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