Caruso Daniel J, Palombo Enzo A, Moulton Simon E, Zaferanloo Bita
Department of Chemistry and Biotechnology, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Department of Engineering Technologies, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Microorganisms. 2022 Oct 8;10(10):1990. doi: 10.3390/microorganisms10101990.
Over the last few decades, many of the existing drugs used to treat infectious diseases have become increasingly ineffective due to the global emergence of antimicrobial resistance (AMR). As such, there is a constant demand to find new, effective compounds that could help to alleviate some of this pressure. Endophytic fungi have captured the attention of many researchers in this field, as they have displayed a vast ability to produce novel bioactive compounds, many of which possess wide-ranging antimicrobial activities. However, while highly promising, research in this area is still in its infancy. Endophytes inhabit the healthy tissues of plants asymptomatically, resulting in a mutualistic symbiosis in which the endophytes produce a plethora of bioactive compounds that support the fitness of the host plant. These compounds display great chemical diversity, representing structural groups, such as aliphatic compounds, alkaloids, peptides, phenolics, polyketides and terpenoids. In this review, the significant antimicrobial potential of endophytic fungi is detailed, highlighting their ability to produce novel and diverse antimicrobial compounds active against human, plant and marine pathogens. In doing so, it also highlights the significant contributions that endophytic fungi can make in our battle against AMR, thus providing the motivation to increase efforts in the search for new and effective antimicrobial drugs.
在过去几十年中，由于全球范围内抗菌药物耐药性（AMR）的出现，许多现有的用于治疗传染病的药物已变得越来越无效。因此，人们一直迫切需要找到新的、有效的化合物，以帮助缓解这种压力。内生真菌已引起该领域许多研究人员的关注，因为它们展现出产生新型生物活性化合物的巨大能力，其中许多化合物具有广泛的抗菌活性。然而，尽管前景十分广阔，但该领域的研究仍处于起步阶段。内生菌无症状地栖息在植物的健康组织中，形成一种互利共生关系，内生菌会产生大量支持宿主植物健康的生物活性化合物。这些化合物具有极大的化学多样性，涵盖脂肪族化合物、生物碱、肽、酚类、聚酮化合物和萜类等结构基团。在这篇综述中，详细阐述了内生真菌巨大的抗菌潜力，突出了它们产生对人类、植物和海洋病原体具有活性的新型多样抗菌化合物的能力。这样做的同时，也强调了内生真菌在我们对抗AMR的斗争中可以做出的重大贡献，从而为加大寻找新的有效抗菌药物的力度提供了动力。
