Cayuela A, Vioque J, Bolumar F
Department of Public Health, Facultad de Medicina de San Juan, Alicante, Spain.
J Epidemiol Community Health. 1991 Dec;45(4):273-6. doi: 10.1136/jech.45.4.273.
The aim of the study was to explore temporal changes in mortality from oesophageal cancer that could be related to tobacco and alcohol consumption.
The study used mortality trends from oesophageal cancer over the period 1951-1985. In addition, available trends on per capita consumption of alcohol and cigarettes are also presented.
Data for this study were derived from Spain's National Institute for Statistics.
Age standardised mortality rates from oesophageal cancer have increased significantly among men in Spain from 1951 to 1985 (p less than 0.01). Mortality rates in women have not changed significantly during the same period, although there is evidence of a certain decrease in recent years. Trends of per capita cigarette consumption from 1957 to 1982 related positively with oesophageal cancer mortality among men, whereas no significant relationship was observed in women. Trends of beer, spirits, and total alcohol consumption were also positively correlated with oesophageal cancer mortality in men. Among women, a weaker relationship was found. Wine consumption showed no relationship with oesophageal cancer mortality either in men or women.
These results are similar to those found in other studies, supporting a role of alcohol (spirits and beer) and cigarette consumption in causation of oesophageal cancer. No relationship was observed with wine consumption.
本研究旨在探讨食管癌死亡率随时间的变化情况，以及这些变化与烟草和酒精消费之间的关系。
本研究采用了1951年至1985年期间食管癌的死亡率趋势。此外，还呈现了人均酒精和香烟消费的现有趋势。
本研究的数据来自西班牙国家统计局。
1951年至1985年期间，西班牙男性的食管癌年龄标准化死亡率显著上升（p<0.01）。同期女性的死亡率没有显著变化，尽管近年来有一定程度的下降。1957年至1982年期间，男性人均香烟消费量的趋势与食管癌死亡率呈正相关，而女性则未观察到显著相关性。啤酒、烈酒和总酒精消费量的趋势也与男性食管癌死亡率呈正相关。在女性中，相关性较弱。无论是男性还是女性，葡萄酒消费与食管癌死亡率均无关联。
这些结果与其他研究的结果相似，支持酒精（烈酒和啤酒）和香烟消费在食管癌病因中的作用。未观察到与葡萄酒消费的关联。
