La Vecchia C, Decarli A, Mezzanotte G, Cislaghi C
J Epidemiol Community Health. 1986 Sep;40(3):257-61. doi: 10.1136/jech.40.3.257.
Trends in death certification rates from the five major alcohol related causes of death in Italy (cancers of the mouth or pharynx, oesophagus, larynx, liver and cirrhosis of the liver) were analysed over a period (1955-79) in which per capita alcohol consumption almost trebled. Age standardised mortality from liver cirrhosis almost doubled in males and increased over 70% in females. In males, mortality from cancers of the upper digestive or respiratory tract showed increases of between 27% and 44%, and liver cancer increased by over 100%. In the late 1970s, the four alcohol related cancer sites accounted for about 12% of all cancer deaths in males and 4.5% in females. Mortality from liver cirrhosis alone accounted for 4.8% of all deaths in males (9.2% of manpower years lost) and 2.3% in females (6.3% manpower years lost) in females. These figures were even higher in selected areas of north eastern Italy, where alcohol consumption is greater. In absolute terms, the upward trends observed correspond to about 10,000 excess deaths per year in the late 1970s compared with rates observed two decades earlier and are thus second only to the increase in tobacco related causes of death over the same calendar period.
对意大利五种主要酒精相关死因(口腔或咽喉癌、食道癌、喉癌、肝癌及肝硬化)的死亡认证率趋势进行了分析,分析时间段为1955年至1979年,在此期间人均酒精消费量几乎增长了两倍。男性肝硬化的年龄标准化死亡率几乎翻了一番,女性则增长了70%以上。在男性中,上消化道或呼吸道癌症的死亡率上升了27%至44%,肝癌则增长了100%以上。在20世纪70年代后期,这四个与酒精相关的癌症部位占男性所有癌症死亡人数的约12%,女性为4.5%。仅肝硬化导致的死亡率在男性中占所有死亡人数的4.8%(损失的人力年数占9.2%),在女性中占2.3%(损失的人力年数占6.3%)。在意大利东北部某些酒精消费量更高的地区,这些数字甚至更高。从绝对数字来看,与二十年前的死亡率相比,20世纪70年代后期观察到的上升趋势每年约对应10000例额外死亡,因此仅次于同一时期与烟草相关的死亡原因的增加。