Conway J, Coats A J
Cardiac Department, John Radcliffe Hospital, Oxford, UK.
J Hypertens Suppl. 1991 Dec;9(8):S57-8.
The reproducibility of blood pressure estimates is considerably improved by ambulatory blood pressure monitoring compared to clinic or office readings. This reduces the number of patients required for clinical trials or improves the statistical power of the trials. Non-uniformity in the response to antihypertensive drugs makes it preferable to use crossover trials with ambulatory monitoring when comparing different antihypertensive agents. However, inherent variability of blood pressure limits the potential of these trials to determine the time-course of the action of drugs.
与诊室或办公室血压读数相比，动态血压监测可显著提高血压估计值的可重复性。这减少了临床试验所需的患者数量，或提高了试验的统计效力。在比较不同的抗高血压药物时，由于对抗高血压药物的反应存在不一致性，因此最好采用动态监测的交叉试验。然而，血压的固有变异性限制了这些试验确定药物作用时间过程的潜力。
