Lira M, Santos L, Azeredo J, Yebra-Pimentel E, Oliveira M Elisabete C D Real
Department of Physics (Optometry), School of Sciences, University of Minho, Portugal.
J Biomed Mater Res B Appl Biomater. 2008 May;85(2):361-7. doi: 10.1002/jbm.b.30954.
The aim of this study was to analyze surface changes of three silicone-hydrogel contact lenses after daily wear. The lenses used in this study were balafilcon A, lotrafilcon B (both surface-treated), and galyfilcon A (non surface-treated).
To understand how and where proteins, lipids, and other contaminants change contact lenses, surface roughness was assessed through Atomic Force Microscopy Tapping Mode. Roughness parameters were Mean Surface roughness (R(a)), Mean-square-roughness (R(q)), and Maximum roughness (R(max)). The surface topography of unworn and worn lenses was also mapped in great detail.
Contact lenses roughness parameters exhibited different values before and after wear and the surface appearance also changed. After wear, balafilcon A and galyfilcon A showed a significant increase on surface roughness parameters, being this increase more accentuated to galyfilcon A. In lotrafilcon B materials no significant changes were observed with wear.
The present study suggests that surface treatment of silicone-hydrogel contact lenses can play a role in the prevention of a significant increase in roughness, and contribute to the better clinical tolerance of these lenses.
本研究旨在分析三种硅水凝胶隐形眼镜在日常佩戴后的表面变化。本研究中使用的镜片为百超菲康A、乐透菲康B（均经过表面处理）和加雷菲康A（未经过表面处理）。
为了解蛋白质、脂质和其他污染物如何以及在何处改变隐形眼镜，通过原子力显微镜轻敲模式评估表面粗糙度。粗糙度参数包括平均表面粗糙度（R(a)）、均方粗糙度（R(q)）和最大粗糙度（R(max)）。还对未佩戴和佩戴后的镜片表面形貌进行了详细测绘。
隐形眼镜的粗糙度参数在佩戴前后呈现不同值，表面外观也发生了变化。佩戴后，百超菲康A和加雷菲康A的表面粗糙度参数显著增加，加雷菲康A的增加更为明显。乐透菲康B材料在佩戴后未观察到显著变化。
本研究表明，硅水凝胶隐形眼镜的表面处理可在防止粗糙度显著增加方面发挥作用，并有助于提高这些镜片的临床耐受性。
