Division of Ophthalmology and Optometry, Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Toruń, Poland.
PLoS One. 2020 Nov 9;15(11):e0242095. doi: 10.1371/journal.pone.0242095. eCollection 2020.
Contact lens wear causes mutual interactions between the ocular surface and the lens, which may affect comfort as well as vision. The aim of this study was to examine deformations in modern positive- and negative-powered silicone hydrogel soft contact lenses (SiH SCLs) after 7 days of continuous wear. This pre-post interventional study included 64 eyes: 42 eyes with myopia of -3.00 D and 22 eyes with hyperopia of +3.00 D. All patients underwent general ophthalmic examination, corneal topography/tomography, total corneal and epithelial thickness mapping, and specular microscopy before and after the wearing period. SiH SCLs made of senofilcon A were worn continuously for 7 days on all eligible eyes. The geometry of the new and used lenses was measured 3 to 6 minutes after removal in two perpendicular planes using a custom-made swept source optical coherence tomography (SS-OCT) system for in vitro measurements. The anterior and posterior radii of curvature decreased in -3.00 D lenses in two perpendicular planes. This effect correlated significantly with average keratometry of the cornea. Sagittal lens height was lower in +3.00 D lens after wear, which correlated moderately with the corneal sagittal height. A significant decrease in central corneal epithelial thickness was observed after wearing +3.0 D lenses. In conclusion, SiH SCLs made of senofilcon A undergo minor deformations after 7-day continuous wear. Geometry modifications are different for -3.00 D and +3.00 D lenses, and they imitate the shape of the anterior eye surface. These geometric changes are accompanied by a decrease in the central thickness of corneal epithelium after +3.00 D lens wear.
软性亲水性硅酮角膜接触镜（Silicone Hydrogel Contact Lens，SiH SCL）在连续佩戴 7 天后的变形研究
接触镜佩戴后会引起眼表与镜片之间的相互作用，这可能会影响佩戴的舒适度和视觉效果。本研究旨在观察现代正、负屈光度的硅酮水凝胶软性角膜接触镜（Silicone Hydrogel Contact Lens，SiH SCL）在连续佩戴 7 天后的变形情况。本研究为前瞻性干预研究，共纳入 64 只眼，近视组 42 只眼，屈光度为-3.00 D；远视组 22 只眼，屈光度为+3.00 D。所有患者在佩戴前后均接受了一般眼科检查、角膜地形图/断层扫描、全角膜和上皮厚度测绘以及共焦显微镜检查。所有符合条件的患者均连续佩戴圣诺菲康（Senofilcon A）硅酮水凝胶软性角膜接触镜 7 天。在去除接触镜后 3 至 6 分钟内，使用定制的扫频源光学相干断层扫描（Swept Source Optical Coherence Tomography，SS-OCT）系统在两个相互垂直的平面上测量新接触镜和使用后的接触镜的几何形状。在两个相互垂直的平面上，-3.00 D 镜片的前、后曲率半径均减小，且与角膜平均角膜曲率呈显著相关。佩戴后+3.00 D 镜片的镜片矢高降低，与角膜矢高呈中度相关。佩戴+3.0 D 镜片后，中央角膜上皮厚度显著降低。总之，圣诺菲康硅酮水凝胶软性角膜接触镜在连续佩戴 7 天后会发生轻微变形。-3.00 D 和+3.00 D 镜片的几何形状变化不同，且它们模仿了前眼部表面的形状。在佩戴+3.00 D 镜片后，这些几何变化伴随着中央角膜上皮厚度的减少。
