Corda Andrea, Corda Francesca, Caivano Domenico, Saderi Laura, Sotgiu Giovanni, Mollica Alessandra, Birettoni Francesco, Porciello Francesco, Pinna Parpaglia Maria Luisa
Department of Veterinary Medicine, Veterinary Teaching Hospital, University of Sassari, Sassari, Italy.
Department of Veterinary Medicine, Veterinary Teaching Hospital, University of Perugia, Perugia, Italy.
J Vet Intern Med. 2020 Nov;34(6):2337-2344. doi: 10.1111/jvim.15891. Epub 2020 Sep 19.
Systemic hypertension (SH) is a persistent and pathological increase in arterial blood pressure (BP). Chronic SH leads to an increase in aortic (Ao) stiffness, and measuring Ao elasticity is useful for estimating Ao stiffness in humans. Currently, no literature in veterinary medicine describes noninvasive assessment of abdominal Ao elasticity in dogs with SH.
Compare ultrasonographic-derived abdominal Ao strain (AoSt) between hypertensive (HT) and normotensive (NT) dogs.
Fifty privately-owned dogs with clinical signs, conditions, or both potentially associated with SH.
Prospective observational case-control study. Aortic stiffness was estimated by calculating AoSt as follows: AoSt = ([AoDs - AoDd]/AoDd) × 100, where AoDs and AoDd are the Ao diameter in systole and in diastole, respectively. Aortic stiffness was calculated from 2 different Ao transverse sections, the first caudal to the left renal artery (K_AoSt), and the second cranial to the external iliac arteries (I_AoSt).
Thirty-two dogs were included in the HT group and 18 in the NT group. Both K_AoSt and I_AoSt in HT dogs were significantly lower (P < .05) than in NT dogs (7.4 ± SD 3.6) vs 10.3 (±3.8) and 5.7 (interquartile range [IQR], 3.9-7.5) vs 8.1 (IQR, 7-10.3), respectively. Only K_AoSt was significantly influenced by age.
Ultrasonographic Ao elasticity assessment was feasible to compare HT and NT dogs. Results indicated that K_AoSt and I_AoSt indices can be used to assess SH-related Ao stiffness, especially when indirect BP measurements are inconsistent or inaccurate. Additional studies to assess the AoSt in healthy dogs of various ages are needed.
系统性高血压（SH）是动脉血压（BP）持续病理性升高。慢性SH导致主动脉（Ao）僵硬度增加，测量Ao弹性有助于评估人类的Ao僵硬度。目前，兽医学领域尚无文献描述对患有SH的犬进行腹部Ao弹性的无创评估。
比较高血压（HT）犬和正常血压（NT）犬超声测量的腹部Ao应变（AoSt）。
50只 privately-owned犬，具有可能与SH相关的临床症状、病症或两者皆有。
前瞻性观察性病例对照研究。通过如下计算AoSt来估计主动脉僵硬度：AoSt = （[AoDs - AoDd]/AoDd）×100，其中AoDs和AoDd分别为收缩期和舒张期的Ao直径。从2个不同的Ao横断面计算主动脉僵硬度，第一个位于左肾动脉尾侧（K_AoSt），第二个位于髂外动脉头侧（I_AoSt）。
HT组纳入32只犬，NT组纳入18只犬。HT犬的K_AoSt和I_AoSt均显著低于NT犬（P < 0.05），分别为7.4（±标准差3.6）对10.3（±3.8）以及5.7（四分位数间距[IQR]，3.9 - 7.5）对8.1（IQR，7 - 10.3）。只有K_AoSt受年龄显著影响。
超声评估Ao弹性对于比较HT犬和NT犬是可行的。结果表明，K_AoSt和I_AoSt指数可用于评估与SH相关的Ao僵硬度，尤其是在间接血压测量不一致或不准确时。需要进一步研究评估不同年龄健康犬的AoSt。
